Researchers Find Link Between Inflammation, Tissue Regeneration and Wound Repair Response

Discovery has implications for potential new treatments of some cancers and inflammatory bowel disease –

Almost all injuries, even minor skin scratches, trigger an inflammatory response, which provides protection against invading microbes but also turns on regenerative signals needed for healing and injury repair – a process that is generally understood but remains mysterious in its particulars.

Writing in the February 25 online issue of Nature, an international team of scientists, headed by researchers at the University of California, San Diego School of Medicine, report finding new links between inflammation and regeneration: signaling pathways that are activated by a receptor protein called gp130.. … Read the full story from the UC San Diego Newsroom


Dr. William SandbornStudy coinvestigators included Division of Gastroenterology division chief William Sandborn, MD, and Inflammatory Disease Center researchers Brigid S. Boland and John T. Chang.

Other Department of Medicine coauthors included Petrus R. de Jong; and Samuel B. Ho, professor of medicine in the Division of Gastroenterology and Section Chief, Gastroenterology, at the VA San Diego Healthcare System.

Full text of the article (UC San Diego only)

Take the 2015 UC San Diego Student Satisfaction Survey

If you are a graduate or undergraduate student at UC San Diego, you are invited to take the 2015 UC San Diego Student Satisfaction Survey. You can take the survey at http://studentsat.ucsd.edu from January 12 through March 12, 2015.

When you complete the survey, you are automatically entered to win an iPad Air 2 or one of eight $100 UC San Diego Bookstore gift cards.

A new prize this year is a GoPro Hero and accessories. For a chance to win it, post a selfie showing your Triton Pride on http://tinyurl.com/studentsatselfie after you have completed the survey. The selfie with the most likes by March 12 will win the GoPro Hero.

2015 Student Satisfaction Survey Poster in Gold

iPad Air 2® is a trademark of Apple Inc., registered in the U.S. and other countries. GoPro Hero is a trademark of GoPro, Inc.

Molecular Link between Obesity and Type 2 Diabetes Reveals Potential Therapy

Inflammatory molecule LTB4 promotes insulin resistance in obese mice and blocking the LTB4 receptor prevents and reverses type 2 diabetes in this model –

Obesity causes inflammation, which can in turn lead to type 2 diabetes. What isn’t well established is how inflammation causes diabetes — or what we can do to stop it. Researchers at University of California, San Diego School of Medicine have discovered that the inflammatory molecule LTB4 promotes insulin resistance, a first step in developing type 2 diabetes. What’s more, the team found that genetically removing the cell receptor that responds to LTB4, or blocking it with a drug, improves insulin sensitivity in obese mice. The study is published Feb. 23 by Nature Medicine. … Read the full story from the UC San Diego Newsroom


Dr. Jerrold OlefskyStudy senior author Jerrold M. Olefsky, MD, is professor of medicine in the Division of Endocrinology and Metabolism and associate dean for scientific affairs for the University of California, San Diego, School of Medicine.

Read article (UC San Diego only)

Doctorate Program Will Study Substance Abuse and Its Consequences

Collaboration between UC San Diego and SDSU among first in nation –

A new Joint Doctoral Program (JDP) in Interdisciplinary Research on Substance Use has been launched by the Division of Global Public Health in the University of California, San Diego School of Medicine and San Diego State University’s School of Social Work. The program will emphasize research devoted to studying the use and misuse of alcohol and drugs – and related social and health consequences. … Read the full story from the UC San Diego Newsroom


Dr. Steffanie Strathdee

Dr. Strathdee.

Co-directors of the program are Steffanie Strathdee, PhD, and Maria Luisa Zúñiga, PhD.

Dr. Strathdee is Associate Dean of Global Health Sciences, head of the UC San Diego Global Health Initiative and Harold Simon Professor and Chief of the Division of Global Public Health at UC San Diego.

Dr. Zúñiga is associate professor and behavioral epidemiologist in the Division of Global Public Health and associate professor in the San Diego State University School of Social Work.

Read the joint doctoral program catalog description

Medtech Meets Cleantech: Malaria Vaccine Candidate Produced from Algae

Cheap, green technique advances efforts toward malaria transmission vaccine in humans —

Researchers at University of California, San Diego School of Medicine used algae as a mini-factory to produce a malaria parasite protein. The algae-produced protein, paired with an immune-boosting cocktail suitable for use in humans, generated antibodies in mice that nearly eliminated mosquito infection by the malaria parasite. The method, published Feb. 17 by Infection and Immunity, is the newest attempt to develop a vaccine that prevents transmission of the malaria parasite from host to mosquito. … Read the full story from the UC San Diego Newsroom


Dr. Joseph VinetzStudy senior author Joseph Vinetz, MD, is professor of medicine in the Division of Infectious Diseases.

Read article abstract

Dr. Sheila Crowe Selected as Vice President of the American Gastroenterological Association

An Announcement from Dr. William J. Sandborn
Professor and Chief, Division of Gastroenterology –

Dr. William Sandborn

Dr. William Sandborn

It is with great pleasure that I share with you that Dr. Sheila Crowe has been selected as Vice President of the American Gastroenterological Association (AGA).

In this role, she will begin a four-year term of service to the AGA, transitioning yearly from Vice President to President Elect to President and finally to Past President and Chair of the AGA Foundation.

Dr. Sheila E. Crowe

Dr. Sheila E. Crowe, Professor of Medicine and Director of Research in the Division of Gastroenterology.

This is perhaps the highest honor that a physician in our specialty can receive. It is a tremendous honor for Dr. Crowe, and for our entire Division.

I am so proud to have Dr. Crowe in our Division. Please join me in congratulating her on this accomplishment.

Best regards,

William J. Sandborn, MD
Professor of Medicine and Adjunct Professor of Surgery
Chief, Division of Gastroenterology
Director, Inflammatory Bowel Disease Center
University of California, San Diego
and UC San Diego Health System

In Memoriam: Nathan J. Zvaifler, MD

An announcement from Wolfgang H. Dillmann, MD, Helen M. Ranney Distinguished Professor and Chair of the Department of Medicine

Dr. Nathan J. Zvaifler

Dr. Nathan J. Zvaifler

Emeritus professor Nathan J. Zvaifler, MD, former chief of the Division of Rheumatology, Allergy & Immunology and a founder and influential leader in the Department of Medicine, passed away on January 28 at the age of 87.

Dr. Zvaifler was internationally known for his research and academic leadership. Here at UC San Diego, he was also beloved for his generosity in teaching and mentorship. Although he retired to emeritus status officially in 2008, he remained active in his instructional activities for years later.

Dr. Zvaifler left his stamp not only on the successful growth of the academic division he led for two decades but also on the character of the Department of Medicine and the School of Medicine.

In 1970, he was recruited from Georgetown University, where he had led the Arthritis Unit since 1961, to head the rheumatology division in the new medical school at UC San Diego.

From 1972 to 1974, he served as acting chair of the Department of Medicine after founding chair Eugene Braunwald left to take a position at the Peter Bent Brigham Hospital of the Harvard Medical School.

This was a period that subsequent Department of Medicine Chair Dr. Helen M. Ranney later described as “a crucial two years in the development of the new School of Medicine at UCSD.”

Dr. Zvaifler spent his entire career at UC San Diego.

A lectureship, the Rheumatology Lectureship Fund, was established in Dr. Zvaifler’s name by the Division of Rheumatology, Allergy and Immunology in 2008. Its purpose is to bring internationally recognized investigators to UC San Diego for seminars and teaching activities. More detail can be found at http://raidivision.ucsd.edu/About/giving/Pages/give-zvaifler.aspx.

Contributions in Dr. Zvaifler’s memory can be made to the Rheumatology Research Foundation of the American College of Rheumatology.

The American College of Rheumatology conducted a 75th Anniversary Interview with Dr. Zvaifler in 2009.

Live Long and Measure: Quest to Create Real-World Tricorder

XPRIZE teams will test Star Trek-inspired medical devices at UC San Diego –

Seeking to boldly go where medical science has not gone before, the Clinical and Translational Research Institute (CTRI) at the University of California, San Diego has been named the official testing site for the $10 million Qualcomm Tricorder XPRIZE, a global competition sponsored by the Qualcomm Foundation to develop a consumer-friendly, mobile device capable of diagnosing and interpreting 15 physiological conditions and capturing vital health metrics.

The XPRIZE competition is inspired by the tricorder medical device that debuted in the original 1966 Star Trek TV show and was frequently featured in subsequent series and movies. …Read the full story from the UC San Diego Newsroom


Dr. Gary FiresteinGary S. Firestein, MD, is director of the CTRI and dean and associate vice chancellor of translational medicine at UC San Diego.

He is professor of medicine in the Division of Rheumatology, Allergy and Immunology and served as division chief from 1998 until he stepped down in 2010 to focus on his growing responsibilities as dean of translational medicine and director of the CTRI for UC San Diego Health Sciences.

Division of Regenerative Medicine Holds First Research Symposium

Catriona H. M. Jamieson, MD, PhD

Dr. Catriona Jamieson

On Friday, January 30, the Division of Regenerative Medicine presented its inaugural symposium on novel research and technologies in regenerative medicine.

The meeting featured scientific presentations by world-renowned academic investigators and industry leaders as well as a discussion panel including keynote speakers Dr. Hans Clevers, Dr. Derrick Rossi, Dr. Carl June and Dr. Wolfgang Dillmann.

Division Chief Catriona Jamieson, MD, PhD, presented the mission and milestones of the new Division of Regenerative Medicine after introductions from UC San Diego Chancellor Pradeep Khosla; Vice Chancellor Health Sciences and Dean of UC San Diego School of Medicine Dr. David Brenner; and Chief Executive Officer of UC San Diego Health System and Associate Vice Chancellor of UC San Diego Health Sciences Paul Viviano.

UC San Diego Moores Cancer Center

UC San Diego Moores Cancer Center

Catriona Jamieson, MD, PhD, is associate professor in the Division of Hematology-Oncology, deputy director of the Sanford Stem Cell Clinical Center, chief of the Division of Regenerative Medicine and director of stem cell research at the Moores Cancer Center.

Take the 2015 UC San Diego Student Satisfaction Survey

If you are a graduate or undergraduate student at UC San Diego, you are invited to take the 2015 UC San Diego Student Satisfaction Survey. You can take the survey at http://studentsat.ucsd.edu from January 12 through March 12, 2015.

When you complete the survey, you are automatically entered to win an iPad Air 2 or one of eight $100 UC San Diego Bookstore gift cards.

A new prize this year is a GoPro Hero and accessories. For a chance to win it, post a selfie showing your Triton Pride on http://tinyurl.com/studentsatselfie after you have completed the survey. The selfie with the most likes by March 12 will win the GoPro Hero.

2015 Student Satisfaction Survey Poster 1

iPad Air 2® is a trademark of Apple Inc., registered in the U.S. and other countries. GoPro Hero is a trademark of GoPro, Inc.