Using microRNA Fit to a T (cell)

Researchers show B cells can deliver potentially therapeutic bits of modified RNA

Researchers at the University of California, San Diego School of Medicine have successfully targeted T lymphocytes – which play a central role in the body’s immune response – with another type of white blood cell engineered to synthesize and deliver bits of non-coding RNA or microRNA (miRNA). … Read the full story from the UC San Diego News Center


Dr. Maurizio ZanettiPrincipal investigator Maurizio Zanetti, MD, is emeritus professor of medicine in the Division of Hematology-Oncology and director of the Laboratory of Immunology at the UCSD Moores Cancer Center.

Dr. Zanetti is the director of tumor immunology for the UCSD Center for Immunology, Infection and Inflammation. He directs the immunology course in the Biomedical Sciences graduate program.

Citation for the study report in Proceedings of the National Academy of Sciences:

Gonzalo Almanza, Veronika Anufreichik, Jeffrey J. Rodvold, Kevin T. Chiu, Alexandra DeLaney, Johnny C. Akers, Clark C. Chen, and Maurizio Zanetti. Synthesis and delivery of short, noncoding RNA by B lymphocytes. PNAS 2013 ; published ahead of print November 25, 2013, doi:10.1073/pnas.1311145110  |  Abstract (Open access)  |  Full text (UCSD only)

Other UCSD news stories about Dr. Zanetti’s work: