Chronic Stress Spawns Protein Aggregates Linked to Alzheimer’s

Repeated stress triggers the production and accumulation of insoluble tau protein aggregates inside the brain cells of mice, say researchers at the University of California, San Diego School of Medicine in a new study published in the March 26 Online Early Edition of the Proceedings of the National Academy of Sciences. … Read the full story from the UCSD Newsroom


Dr. Wylie Vale Dr. Wylie Vale was one of two Salk Institute for Biological Studies researchers who contributed to this research. Dr. Vale, who held an adjunct professorship in the Division of Endocrinology and Metabolism, collaborated on numerous research projects at UC San Diego. He passed away on January 6, 2012.  |  Read memorial

Read abstract of study report

Citation for the study report: Rissman RA, Staup MA, Lee AR, Justice NJ, Rice KC, Vale W, Sawchenko PE. Corticotropin-releasing factor receptor-dependent effects of repeated stress on tau phosphorylation, solubility, and aggregation. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6277-82. doi: 10.1073/pnas.1203140109. Epub 2012 Mar 26.