Tumor Metastasis with a Twist

Protein is key to early embryonic development, but later promotes spread of cancer

In the early stages of human embryogenesis, a transcription factor called Twist1 plays a key regulatory role in how the embryo assumes form and function. Much later in life, however, researchers at the University of California, San Diego School of Medicine, say Twist1 can re-emerge, taking a darker and more deadly turn…. Read the full story from the UCSD Newsroom

Dr. Lucila Ohno-Machado (pictured) and Jihoon Kim of the Division of Biomedical Informatics are among the authors of the study report. Lucila Ohno-Machado, M.D., Ph.D., is professor and chief of the division; Jihoon Kim, M.S., is senior statistician. Read the published article (full text).

Photo of Dr. Ohno-Machado: John Hanacek, Calit2 UC San Diego.