Research with mice reveals possible strategy to reverse fibrosis in liver and other organs
An international team of scientists, led by researchers at the University of California, San Diego School of Medicine, report that significant numbers of myofibroblasts – cells that produce the fibrous scarring in chronic liver injury – revert to an inactive phenotype as the liver heals. The discovery in mouse models could ultimately help lead to new human therapies for reversing fibrosis in the liver, and in other organs like the lungs and kidneys…. Read the full story from the UCSD Newsroom
Senior author of the study report is David A. Brenner, MD, vice chancellor for Health Sciences, dean of the UC San Diego School of Medicine and professor of medicine in the Division of Gastroenterology.
Among the coauthors is Wolfgang H. Dillmann, MD, Helen M. Ranney Professor and Chair, Department of Medicine and translational researcher in the Division of Endocrinology and Metabolism.