Enzyme Offers New Therapeutic Target for Cancer Drugs

Researchers at the University of California, San Diego School of Medicine have uncovered a new signal transduction pathway specifically devoted to the regulation of alternative RNA splicing, a process that allows a single gene to produce or code multiple types of protein variants. The discovery, published in the June 27, 2012 issue of Molecular Cell, suggests the new pathway might be a fruitful target for new cancer drugs. … Read the full story from the UCSD Newsroom


ALTDepartment of Medicine faculty co-author M. Geoffrey Rosenfeld, MD, is distinguished professor of medicine and an investigator in the Howard Hughes Medical Institute.

Read the article summary in Molecular Cell.

Article Citation:
The Akt-SRPK-SR Axis Constitutes a Major Pathway in Transducing EGF Signaling to Regulate Alternative Splicing in the Nucleus
Zhihong Zhou, Jinsong Qiu, Wen Liu, Yu Zhou, Ryan M. Plocinik, Hairi Li, Qidong Hu, Gourisanker Ghosh, Joseph A. Adams, Michael G. Rosenfeld, and Xiang-Dong Fu
10.1016/j.molcel.2012.05.014.

Dr. Rosenfeld’s laboratory