NOTCH1 Signaling Promotes T-Cell Acute Lymphoblastic Leukemia-Initiating Cell Regeneration
Research suggests that patients with leukemia sometimes relapse because standard chemotherapy fails to kill the self-renewing leukemia initiating cells, often referred to as cancer stem cells … A team of researchers – led by Catriona H. M. Jamieson, MD, PhD, associate professor of medicine at the University of California, San Diego School of Medicine and director of Stem Cell Research at UC San Diego Moores Cancer Center – studied these cells in mouse models that had been transplanted with human leukemia cells. They discovered … Read the full story from the UCSD Newsroom
In the study, the investigators successfully block leukemia stem cell self-renewal. Their work was funded in part by a California Institute for Regenerative Medicine (CIRM) Development of Highly Active Anti-Leukemia Stem Cell Therapy (HALT) Leukemia Disease Team Research grant for which Dr. Jamieson serves as co-principal investigator with Dennis A. Carson, MD, former director of the Moores Cancer Center.
The overall goal of the HALT project is to develop six drugs – three monoclonal antibodies and three small molecules – to destroy leukemia stem cells.
Funding also came from the Ratner Family Foundation and the Leichtag Family Foundation. Antibody development was performed by Pfizer.
In her research, Dr. Jamieson focuses on translational studies to develop new treatments for myeloproliferative disorders and leukemia. In 2010, she received a $3.34 million grant from CIRM to support her efforts to develop treatments that reduce the risk of relapse in leukemia. | More about this funded project
Dr. Jamieson was named to the “San Diego’s Top Doctors” list for 2010 and 2011.
- Read the study report in PLoS ONE.
- Citation for study report: Ma W, Gutierrez A, Goff DJ, Geron I, Sadarangani A, et al. (2012) NOTCH1 Signaling Promotes Human T-Cell Acute Lymphoblastic Leukemia Initiating Cell Regeneration in Supportive Niches. PLoS ONE 7(6): e39725. doi:10.1371/journal.pone.0039725
- Dr. Jamieson’s laboratory at the UC San Diego Moores Cancer Center
- Department of Medicine feature story about Dr. Jamieson and her research (2008)