New Way of Fighting High Cholesterol Upends Assumptions

Atherosclerosis – the hardening of arteries that is a primary cause of cardiovascular disease and death – has long been presumed to be the fateful consequence of complicated interactions between overabundant cholesterol and resulting inflammation in the heart and blood vessels. … Read the full story from the UCSD Newsroom


Christopher K. GlassSenior author of the study report is Christopher K. Glass, MD, PhD, pictured at left, professor in the Departments of Medicine and Cellular and Molecular Medicine.

The other Department of Medicine coauthors on the study report are Andrew C. Li, MD, PhD, assistant professor of medicine in the Division of Endocrinology and Metabolism; Sotirios Tsimikas, MD, FACC, professor of clinical medicine in the Division of Cardiovascular Medicine; and Oswald Quehenberger, PhD, professor of medicine in the Division of Endocrinology and Metabolism.

Read the report of the study in Cell (full text UCSD only)

Citation of study report: Spann NJ, Garmire LX, McDonald JG, Myers DS, Milne SB, Shibata N, Reichart D, Fox JN, Shaked I, Heudobler D, Raetz CRH, Wang EW, Kelly SL, Sullards MC, Murphy RC, Merrill AH Jr, Brown HA, Dennis EA, Li AC, Ley K, Tsimikas S, Fahy E, Subramaniam S, Quehenberger O, Russell DW, Glass CK. Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell 151(1):138-152, 2012. http://dx.doi.org/10.1016/j.cell.2012.06.054