Dr. Rohit Loomba on Fatty Liver Disease: HHMI Bulletin

Dr. Rohit LoombaDr. Rohit Loomba, a UCSD hepatologist who specializes in fatty liver disease, is interviewed in an article about the disease in the Fall 2012 health bulletin from the Howard Hughes Medical Institute.

In “The Fat You Can’t See,” Loomba describes the rising incidence of fatty liver disease and points to society’s general increase in dietary sugar intake as a major cause. He emphasizes the importance of identifying individuals who are at highest risk for developing the disease and he predicts there will be a dramatic increase in our understanding of the disease in the next five years.

Rohit Loomba, MD, MHSc, is assistant professor of clinical medicine in the Division of Gastroenterology. He also holds an appointment in the Division of Epidemiology in the Department of Family and Preventive Medicine.

Loomba conducts his clinical practice in UC San Diego Health System’s liver disease clinics. In his research laboratory, he conducts a variety of studies of nonalcoholic fatty liver disease (NAFLD), including a number of clinical trials.

With a four-year mentored patient-oriented research career development grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Loomba is investigating the genetic epidemiology of NAFLD in a twin-pair study. In that work, his mentors are UCSD researchers Daniel T. O’Connor, MD, professor of medicine and pharmacology; Elizabeth Barrett-Connor, MD, distinguished professor and chief of the Division of Epidemiology in the Department of Family and Preventive Medicine; and David Brenner, MD, Vice Chancellor for Health Sciences and Dean of the School of Medicine.

Loomba serves as the UCSD site principal investigator for the Nonalcoholic Steatohepatitis Clinical Research Network (NASH-CRN) studies in adult patients with NAFLD. NASH-CRN, an NIDDK-sponsored research consortium funded via a UO1 research program-cooperative agreement mechanism, aims to improve understanding of the natural history, pathophysiology and management of NAFLD.

In addition, he is the founding director and principal investigator of the San Diego Integrated NAFLD Research Consortium (SINC), which includes four centers: UCSD, Kaiser Permanente Health System, Sharp Health System, and Balboa Naval Medical Center. SINC is a collaborative network that allows community-based patients to participate in NAFLD studies conducted at UCSD.

Loomba has established a major NAFLD research program at UCSD with recently published investigator-initiated treatment studies in NASH (Le et al., Hepatology September 2012) and several in progress.

In various NAFLD translational research studies currently ongoing at UCSD, Loomba collaborates with Drs. Jerrold Olefsky, David Brenner, Claude Sirlin, Bernd Schnabl, Lars Eckmann, Edward Dennis, Ariel Feldstein and Ekihiro Seki.

He also directs the UCSD fellowship training program in liver epidemiology and patient-oriented outcomes research.

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