A New Protein Target for Controlling Diabetes

Researchers at the University of California, San Diego School of Medicine have identified a previously unknown biological mechanism involved in the regulation of pancreatic islet beta cells, whose role is to produce and release insulin. The discovery suggests a new therapeutic target for treating dysfunctional beta cells and type 2 diabetes, a disease affecting more than 25 million Americans. … Read the full story from the UCSD Newsroom


Dr. Jerrold OlefskyPrincipal Investigator Jerrold M. Olefsky, MD, is Associate Dean for Scientific Affairs and Distinguished Professor of Medicine in the Division of Endocrinology and Metabolism.

Study report coauthors from the Department of Medicine are Hui Dong, PhD, associate professor of medicine in the Division of Gastroenterology; and Yun Sok Lee, Hidetaka Morinaga, and William Lagakos in the Division of Endocrinology and Metabolism.

Citation for the report: Yun Sok Lee, Hidetaka Morinaga, Jane J. Kim, William Lagakos, Susan Taylor, Malik Keshwani, Guy Perkins, Hui Dong, Ayse G. Kayali, Ian R. Sweet, Jerrold Olefsky. The Fractalkine/CX3CR1 System Regulates β Cell Function and Insulin Secretion. Cell – 11 April 2013 (Vol. 153, Issue 2, pp. 413-425)  |  Read the report summary

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