Tumor-Activated Protein Promotes Cancer Spread

Researchers at the University of California, San Diego School of Medicine and UC San Diego Moores Cancer Center report that cancers physically alter cells in the lymphatic system – a network of vessels that transports and stores immune cells throughout the body – to promote the spread of disease, a process called metastasis.  … Read the full story from the UCSD Newsroom


Dr. Judith VarnerJudith Varner, PhD, is senior author of the study report. She is professor of medicine in the Division of Hematology-Oncology and an investigator in the Solid Tumor Therapeutics Program at the UC San Diego Moores Cancer Center.

Citation for the study report:
PI3Kα activates integrin α4β1 to establish a metastatic niche in lymph nodes. Barbara Garmy-Susini, Christie J. Avraamides, Jay S. Desgrosellier, Michael C. Schmid, Philippe Foubert, Lesley G. Ellies, Andrew M. Lowy, Sarah L. Blair, Scott R. Vandenberg, Brian Datnow, Huan-You Wang, David A. Cheresh, and Judith Varner. PNAS 2013 ; published ahead of print May 13, 2013, doi:10.1073/pnas.1219603110  |  Abstract  |  Read the article (PDF) (UCSD only)