Cholesterol Sets Off Chaotic Blood Vessel Growth

A study at the University of California, San Diego School of Medicine identified a protein that is responsible for regulating blood vessel growth by mediating the efficient removal of cholesterol from the cells. Unregulated development of blood vessels can feed the growth of tumors.  … Read the full story from the UCSD Newsroom


Dr. Yury MillerYury Miller, MD, PhD, left, is senior author of the study report. He is associate professor of medicine in the Division of Endocrinology & Metabolism and faculty member in the Biomedical Sciences Graduate Program.

He first joined UC San Diego as a postdoctoral fellow in Dr. Joseph Witztum’s laboratory in 1998.

Miller is principal investigator of a National Institutes of Health R01 research grant, “Zebrafish Models of Vascular Inflammation and Atherosclerosis,” and a subproject of a P01 research program project with the La Jolla Institute of Allergy & Immunology, “Oxidized lipids and endotoxemia in vascular inflammation.”

Longhou Fang, PhDFirst author Longhou Fang, PhD, left, is a postdoctoral fellow in the Miller laboratory. He is the recipient of a National Institutes of Health K99 postdoctoral award for the project, “AIBP-mediated cholesterol efflux and angiogenesis.”

The other coauthors excepting Drs. Ulrich and Torres-Vásquez are affiliated with the Department of Medicine.

Dr. Philipp Wiesner.

Second-year internal medicine resident Philipp Wiesner, MD, right, who chose Miller as one of his mentors for the investigations he performed during his residency program research rotation, presented data from the vascular inflammation project at Medicine Grand Rounds on May 15.

Wiesner is also a coauthor of the study reported in Nature.

Citation for the study report:  Longhou Fang, Soo-Ho Choi, Ji Sun Baek, Chao Liu, Felicidad Almazan, Florian Ulrich, Philipp Wiesner, Adam Taleb, Elena Deer, Jennifer Pattison, Jesús Torres-Vázquez, Andrew C. Li & Yury I. Miller. Control of angiogenesis by AIBP-mediated cholesterol efflux. Nature (2013) doi:10.1038/nature12166. Published online 29 May 2013.  |  Read the full text (UCSD only)

More Information

Other UC San Diego news stories about Miller’s work:

Philipp Wiesner’s May 15 Medicine Grand Rounds presentation “Oxidized Phospholipids in Inflammation and Atherosclerosis”  |  Watch video (UCSD only)