Urine Biomarkers Reveal Mitochondrial Dysfunction in Diabetic Kidney Disease

Researchers at the University of California, San Diego School of Medicine have identified 13 metabolites – small molecules produced by cellular metabolism – that are significantly different in patients with diabetes and chronic kidney disease compared to healthy controls. … Read the full story from the UC San Diego News Center


Kumar Sharma, MD, FAHA First author Kumar Sharma, MD, FAHA, is professor of medicine and director of the Center for Renal Translational Medicine in the Division of Nephrology-Hypertension.

Citation for the study report:

Metabolomics Reveals Signature of Mitochondrial Dysfunction in Diabetic Kidney Disease. Kumar Sharma, Bethany Karl, Anna V. Mathew, Jon A. Gangoiti, Christina L. Wassel, Rintaro Saito, Minya Pu, Shoba Sharma, Young-Hyun You, Lin Wang, Maggie Diamond-Stanic, Maja T. Lindenmeyer, Carol Forsblom, Wei Wu, Joachim H. Ix, Trey Ideker, Jeffrey B. Kopp, Sanjay K. Nigam, Clemens D. Cohen, Per-Henrik Groop, Bruce A. Barshop, Loki Natarajan, William L. Nyhan, and Robert K. Naviaux JASN ASN.2013020126; published ahead of print October 10, 2013, doi:10.1681/ASN.2013020126  |  Full text (UCSD only)

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