Protein That Protects During Stress Sheds Light on How Diabetes Drug Prevents Tumors

Researchers at University of California San Diego School of Medicine have identified a previously unknown mechanism that helps fortify the structure and tight junctions between epithelial cells — a basic cell type that lines various body cavities and organs throughout the body, forming a protective barrier against toxins, pathogens and inflammatory triggers. Breaches of this barrier can provoke organ dysfunction and development of tumors.

The findings, published online in the current issue of eLife by senior author Pradipta Ghosh, MD … Read the Full Story from the UC San Diego Newsroom


Dr. Pradipta Ghosh

Pradipta Ghosh, MD

Pradipta Ghosh, MD, MBBS, is Professor of Medicine in the Division of Gastroenterology.

She is a graduate of the UC San Diego Internal Medicine Residency Training Program, the Gastroenterology Fellowship Training Program and the Department of Medicine Physician-Scientist Training Program.

Two Research Award-Winning Medical Residents to Present Grand Rounds This Week

Drs. Trisha Sharma and Ahnika Kline, two internal medicine residents who won research awards for their posters at this year’s UC San Diego Internal Medicine Residency Program Research Symposium, will present their work at Medicine Grand Rounds on June 1.

Trisha Sharma, MD

R2 Trisha Sharma, MD, left, will present on “Gastrointestinal Manifestations of Common Variable Immunodeficiency Disorder.”

Ahnika Kline, MD, PhDDr. Sharma received her MD degree from Rutgers New Jersey Medical School.

R3 Ahnika Kline, MD, PhD, right, will present “Quality Improvement in Internal Medicine: A Test Case of Hepatitis C.” In 2016-2017, Dr. Kline will be VA Chief Resident in Quality and Safety. She received her MD degree from UC San Francisco.

New UC San Diego Center Will Focus on Heart Health Among Latinas

Researchers at the University of California, San Diego School of Medicine have launched a new four-year, $3.7 million multidisciplinary research center to investigate the relationship between sedentary behavior and cardiovascular risk factors in Latinas, who have a disproportionately higher chance of developing heart disease than the general population.

The study is part of a new Strategically Focused Research Network created and funded by the American Heart Association (AHA). … Read the Full Story from the UC San Diego Newsroom


Dorothy Sears, PhD

Dorothy Sears, PhD

Within the multidisciplinary research center, Dorothy Sears, PhD, Associate Professor of Medicine in the Division of Endocrinology & Metabolism, will conduct studies to find and characterize biomarkers of cardiovascular disease risk associated with sedentary behavior.

Internal Medicine Residents to Present Their Research at May 5 Symposium

UC San Diego Internal medicine residents who took part in a research block during this academic year will present their work in a poster session at the Second Annual UC San Diego Internal Medicine Resident Research Symposium on May 5, 2016, from 6 to 9 p.m.

Wolfgang H. Dillmann, MD

Wolfgang H. Dillmann, MD

The symposium hosts are Wolfgang Dillmann, MD, Helen M. Ranney Distinguished Professor and Chair of the Department of Medicine; Simerjot K. Jassal, MD, Director of the Internal Medicine Residency Program; and Lori Wan, MD, Director of the Combined Medicine-Pediatrics Residency Program.

Simerjot K. Jassal, MD

Simerjot K. Jassal, MD

“We think this will be a wonderful way for residents who have participated in research to share their accomplishments, and to inspire residents who plan to participate in the future,” said Dr. Jassal.

Lori Wan, MD

Lori Wan, MD

“We hope this will also serve to fuel future projects and create more mentorship opportunities for our residents.”

Last year, 34 residents presented their research at the symposium, which attracted more than 80 residents and faculty members.

This year’s symposium will take place at the Medical Education and Telemedicine (MET) Building Learning Centers (Rooms 141-143) on the School of Medicine campus in La Jolla.

Faculty members and trainees are encouraged to attend. The Internal Medicine Resident Research Symposium RSVP link is http://evite.me/VedAcYKWVS (Safari, Firefox or Chrome browsers only).

Resident research topics and publications from prior years are posted on the Internal Medicine Residency Program website.

March Matchness 2016

In just five days, a lot of future doctors will learn where they will do their first doctoring —

Each year, at precisely the same moment – noon on the east coast, 9 a.m. on the west – thousands of graduating medical school students across the country simultaneously tear open an envelope. Inside, there is a single sheet of paper and on it, a handful of words. Those words will inform each graduate where he or she will do their residencies, where each will spend the first several years of their careers as working doctors.

It’s called Match Day. Started in 1952 and operated by the non-profit National Resident Matching Program, the event culminates months of applications and interviews by fourth-year medical school students, each of whom may have visited a dozen or more hospitals and institutions across the country in search of their perfect match. … Read the Full Story from the UC San Diego Newsroom

Medicine Grand Rounds Resumes on August 26

The 2015-2016 season of Medicine Grand Rounds begins on August 26 with the Sixth Annual Nathan J. Zvaifler Lecture in Rheumatology presented by Dr. Lindsey Criswell of UCSF.

Lindsey A. Criswell, MD, MPH, is chief of the Division of Rheumatology at UCSF and a renowned researcher in human autoimmune disease. She will speak on the topic, “Refining Genotype-Phenotype Associations in Systemic Lupus Erythematosus.”

Dr. Nathan J. Zvaifler

Dr. Zvaifler

Nathan J. Zvaifler, MD, was a founder and influential leader in the Department of Medicine and former chief of the Division of Rheumatology, Allergy & Immunology.

The division established the annual Nathan J. Zvaifler Rheumatology Lectureship upon Dr. Zvaifler’s formal retirement in 2008. Dr. Zvaifler passed away in January of this year.

Medicine Grand Rounds takes place on Wednesday mornings at 7:30 a.m. in the Liebow Auditorium on the second floor of the Biomedical Sciences Building on the School of Medicine campus in La Jolla.

Instructions for viewing live streaming and archived video of Medicine Grand Rounds presentations can be found on the Medicine Grand Rounds page.

Medicine 401 Teaching Award Winners Announced

The winners of the 2015 Medicine 401 Teaching Awards were announced at an awards ceremony on May 27. Granted by the third-year medical students each year, the awards go to residents and attending physicians for their excellence in teaching on the wards at the Veterans Administration San Diego Healthcare System and the UC San Diego Medical Center in Hillcrest.

The winners:

VA Wards Resident Award: Dr. Tyler Woodell
Hillcrest Wards Resident Award: Dr. Michelle Pearlman

VA Wards Attending Award: Dr. Mara Zulauf
Hillcrest Wards Attending Award: Dr. Darcy Wooten

“There were many kind words of praise and admiration in the comments from the students who worked with Drs. Pearlman and Woodell,” said residency program director Simerjot Jassal, MD. “Congratulations to these outstanding doctors!”

The medical students’ comments included the following.

Dr. Michelle Pearlman

Dr. Michelle Pearlman

Of Michelle Pearlman, MD: … Really focused on teaching … worked hard during the rotation to make sure we were achieving our own goals and learning as much as possible … gave excellent feedback … made great teaching points during rounds … great example of professionalism … will make an excellent teacher … great role model … clear and detailed expectations … we knew exactly what to work on and how to succeed … one of the best residents with whom I have worked … gave frequent feedback enabling me to improve daily … strong leadership skills, a positive attitude, and a great work ethic … will make an amazing GI fellow and attending.

Dr. Pearlman has matched to a fellowship program in gastroenterology at University of Texas Southwestern Medical Center in Dallas.

Dr. Tyler Woodell

Dr. Tyler Woodell

Of Tyler Woodell, MD: Always made it a priority to have a teaching point every day … always willing to make sure all of our questions were answered and that we were engaged in patient care … went out of his way to make sure we had a good learning experience … an exceptional model physician who I would recommend to any student as a preceptor and any patient as a doctor … focused on making sure that we learned as much as possible … carved out time to talk through our assessment and plans with us … took time on rounds to talk through key issues with us …both a fantastic role model for compassionate patient care and bedside manner as well as an engaging teacher … clearly loved to teach … not only an outstanding teacher, but also very compassionate with patients.

Dr. Woodell has matched to a fellowship program in nephrology at Oregon Health & Science University.

Internal Medicine Resident Drs. Noel Lee, Satya (Nanu) Das and Michele Pham Present Research at Medicine Grand Rounds

Three internal medicine residents who were among six winners at the First Annual Internal Medicine Residency Program Research Symposium on May 7 will present their research at Medicine Grand Rounds June 10:

Noel Lee, MD – The Prevalence of Coronary Artery-Pulmonary Artery Collaterals in Patients with Chronic Thromboembolic Pulmonary Hypertension

Satya (Nanu) Das, MD – The Role for Cell Free Circulating DNA in Detecting Secondary EGFR Mutations in Advanced Stage Non-Small Cell Lung Cancer Patients

Michele Pham, MD – Decreased BDNF in Aspirin Exacerbated Respiratory Disease

Internal Medicine Resident Drs. Julie Chen and Darrin Wong Present Research at Department of Medicine Grand Rounds

Drs. Darrin Wong and Julie Chen at Medicine Grand Rounds.

Drs. Darrin Wong and Julie Chen at Medicine Grand Rounds.

On June 3, 2015, Drs. Julie Chen and Darrin Wong presented their research at Department of Medicine Grand Rounds.

The subject of Dr. Chen’s research was “Failure to Adjust Diabetes Medications at Discharge for Hospitalized Patients with Poorly Controlled Diabetes.”

Dr. Chen worked with members of the faculty in the Division of Endocrinology and Metabolism, including Drs. Robert El-Kareh and Kristen Kulasa as well as Dr. Pedro Ramos from the Division of Hospital Medicine.

Dr. Wong presented his research on the topic, “Right Ventricular Dyssynchrony in CTEPH.” He worked with Dr. Daniel Blanchard from the Division of Cardiovascular Medicine.

Dr. Wong presenting background information about echocardiography.

Dr. Wong presenting background information about echocardiography.

Drs. Chen and Wong won their places at Medicine Grand Rounds when they were chosen for their admirable research achievements at the UC San Diego Annual Internal Medicine Resident Research Symposium on May 7.

The other research symposium winners were Drs. Satya Das, Noel Lee, Michele Pham and Kevin Shah. Drs. Das, Lee, and Pham will present their research at Medicine Grand Rounds on June 10.

Dr. Shah presented his research, along with fellow resident Dr. Nick Marston, on the topic, “Serial Sampling of Copeptin Levels Improves Diagnosis and Risk Stratification in Patients Presenting with Chest Pain: Results from the CHOPIN Trial” last June.

2015 Resident Research Symposium Winners

Research winners at last month’s Annual Internal Medicine Resident Research Symposium. Left to right: Drs. Shah, Lee, Das, Chen, Pham and Wong.

Resident Research Symposium: 34 Residents Present Work, Six Chosen to Speak at Medicine Grand Rounds

2015 Resident Research Symposium Winners

From left: Drs. Kevin Shah, Noel Lee, Nanu Das, Julie Chen, Michele Pham and Darrin Wong.

The Internal Medicine Residency Program presented its first annual Resident Research Symposium to a full crowd on Thursday, May 7, with presentations from 34 residents who have taken part in the program’s research block in the last two academic years.

“The 2015 UCSD Internal Medicine Resident Research Symposium was an incredible success,” said program director Simerjot Jassal, MD. “It was a terrific opportunity to showcase the amazing scholarly work our residents have been doing under the outstanding mentorship of our committed faculty,” she said.

Of the 34 residents taking part in the symposium, six were selected to present at Medicine Grand Rounds on June 3 and June 10. Pictured above, they are (from left) Drs. Kevin Shah, Noel Lee, Nanu Das, Julie Chen, Michele Pham and Darrin Wong.

More than 80 residents and faculty members attended.

“I was thrilled with the turnout,” Dr. Jassal said. “The enthusiasm in the room was palpable.”

Dr. Schafer Boeder presenting his research.In the photo at left, Dr. Schafer Boeder discusses his research project.

The Department of Medicine and Helen M. Ranney Distinguished Professor and Chair Wolfgang Dillmann, MD, supported the event. Its purpose is to inspire future projects and create more mentorship opportunities.

“I am so proud of our residents,” Dr. Jassal said.