Photo of Dr. Sean DeWolf MD

Sean DeWolf, MD

Pulmonary, Critical Care & Sleep MedicineUC San Diego Department of Medicine


Dr. DeWolf was born and raised in Oakland, CA. After high school, he left the California sunshine for the east coast, where he attended Villanova University. He spent the latter two years of his undergraduate education studying B cell development in a basic science lab, which ultimately proved to be the beginning of a great passion for bench research and immunology. After graduation he spent a year in southern Mexico before returning to California for his medical school at UCSD. He began working in a lab that studied how innate immunity initiated and propagated acute kidney injury and thought he would end up as a transplant nephrologist. During his 4th year of medical school, however, he rotated through the ICU and fell in love with critical care medicine. He stayed at UCSD for his residency and continued to work in the research area that he now intends to make his career. He enjoys playing golf and basketball and taking his dog on walks with his wife.

Education & Training
2016-2019: Residency, University of California San Diego
2012-2016: M.D. University of California San Diego, School of Medicine
2007-2011: Bachelor of Sciences; Villanova University

Research Interests
1. Innate immunity in acute lung injury and acute kidney injury
2. Lung-kidney interaction during critical illness
3. Cell signaling and molecular biology

Key Publications
1. DeWolf, SE, Shigeoka AA, Scheinok A, Kasimsetty SG, Welch AK, McKay BD. Expression of TLR2, NOD1, and NOD2 and the NLRP3 inflammasome in Renal Tubular Epithelial Cells of Male versus Female mice. Nephron. 2017; 137 (1): 68-76
2. Kasimsetty SG, DeWolf SE, Shigeoka AA, McKay DB. Regulation of TLR2 and NLRP3 in Primary Murine Renal Tubular Epithelial Cells. Nephron Clin Pract 2014; 127: 119-123.
3. Jones MA, DeWolf SE, Vacharathit V, Yim M, Spencer S, Bamezai AK. Investigating B cell development, natural and primary antibody responses in Ly-6A/Sca-1deficient mice. PLOS ONE. 2016; 11 (6)

1. UC San Diego Internal Medicine Grand Rounds. Absence of NOD1 and NOD2 Increases Pulmonary Inflammation Following Renal Ischemia-Reperfusion Injury.  June 2018