Lars Eckmann, MD, has received a two-year, nearly $1 million grant from the National Institute of Dental and Craniofacial Research for his study, “Click chemistry for novel antimicrobials against periodontal pathogens.”
The funding comes from the NIH Challenge Grants in Health and Science Research program, a part of the 2009 federal stimulus package.
Dr. Eckmann’s project will focus on developing new, very specific antibiotics to treat periodontal disease. Read the abstract of Dr. Eckmann’s grant
Periodontitis, which affects a large number of Americans, can cause tooth loss and has been associated with systemic diseases including diabetes, cardiovascular disease, and respiratory problems.
Current antibiotic therapies for periodontitis are predominantly administered systemically, but the resulting side effects limit their use in treating early-stage disease.
Dr. Eckmann, Professor of Medicine in the Division of Gastroenterology, directs the Animal Model Core of the Center for Tissue Repair, Epithelial Biology and Inflammation, and Transformation (C-TREAT), which is UCSD’s Digestive Disease Research Development Center.
In his research, Dr. Eckmann focuses on intestinal and systemic responses to microbial infection, mucosal immunology, and the pathophysiology of intestinal inflammation.