Dr. Pradipta Ghosh

Three years ago, Department of Medicine physician-scientist Dr. Pradipta Ghosh received a Doris Duke Charitable Foundation Clinical Scientist Development Award to support her in the transition from junior researcher to independent investigator.

The grant funded her research for three fruitful years as she moved from assistant to associate professor and landed a five-year R01 research grant from the National Cancer Institute.

Now, Ghosh has won DDCF funding again — this time a Clinical Research Mentorship Grant to support her in mentoring medical student Gary Ma in the project, “Molecular Rheostats in Type II Diabetes – Novel Therapeutic Targets for Insulin Resistance.”

The DDCF Clinical Research Mentorship program is a competitive grant program that supports the development of a mentoring relationship between a clinical scientist previously funded through the foundation and a medical student with an interest in becoming a future clinician investigator.

This DDCF program funded 10 mentor/mentee teams this year.

About Dr. Ghosh

Pradipta Ghosh, MD, MBBS, is associate professor of medicine in the Division of Gastroenterology. She is a graduate of the UC San Diego Internal Medicine Residency Training Program, the Gastroenterology Fellowship Training Program and the Department of Medicine Physician-Scientist Training Program.

In her laboratory, Ghosh investigates the cell biology of signal transduction to find new ways to understand and block the development and spread of cancer and other diseases. Her National Cancer Institute research grant supports the project, “Modulation of G Proteins by Growth Factors.”

Looking back at the development of her career, she cites two important mentors, Drs. Stuart Kornfeld and Marilyn Farquhar.

“Stuart Kornfeld and Marilyn Farquhar are spectacular examples of good mentors and what good mentoring involves,” she said. “Being accessible, empowering, ensuring the freedom to probe, to expand the horizon.”

Stuart Kornfeld, MD, is David C. and Betty Farrell Distinguished Professor of Medicine and Director of the Division of Hematology at Washington University in St. Louis, where he directs the Medical Scientist Training Program and co-directs the Physician-Scientist Training Program.

Marilyn Farquhar, PhD, is Distinguished Professor of Cellular and Molecular Medicine and Pathology at UC San Diego.

About Her Mentor/Mentee Research Project

Abstract of the Study, “Molecular Rheostats in Type II Diabetes – Novel Therapeutic Targets for Insulin Resistance.”

“The overall goal of the proposed research is to unravel the mechanisms by which [Gα-interacting, vesicle-associated protein] (GIV) maintains insulin sensitivity and how its phosphoinhibition generates Insulin resistance (IR). Insights gained will not only help determine whether GIV can serve as a therapeutic target and a marker for prognosticating response to therapy in patients with IR, but also help decipher, access, and manipulate the entire signaling network to restore physiologic insulin response.”

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