Dr. Jerrold M. Olefsky and colleagues have reported a discovery that suggests a new way to treat obesity-related insulin resistance and Type 2 diabetes.
In a laboratory study, they found that insulin resistance could be reversed by lowering the amount of adipose tissue macrophages (ATMs) in tissue.
ATMs normally help fight infection, but in obesity they accumulate in fat tissue and can become triggers for inflammation. The inflammation is a factor in the development of insulin resistance and Type 2 diabetes.
Jerrold M. Olefsky, M.D., is Distinguished Professor of Medicine in the Division of Endocrinology and Metabolism and Associate Dean for Scientific Affairs. Co-leader of the study is Jaap Neels, Ph.D., a former UCSD colleague.
Their Division of Endocrinology and Metabolism coauthors are researchers David Patsouris, Ph.D., Ping-Ping Li, and Divya Thapar.
The report is published in the October 8 issue of the journal Cell Metabolism. The full citation:
Patsouris D, Li PP, Thapar D, Chapman J, Olefsky JM, Neels JG. Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab 2008 Oct;8(4):301-309. Read the article abstract