Medtech Meets Cleantech: Malaria Vaccine Candidate Produced from Algae

Cheap, green technique advances efforts toward malaria transmission vaccine in humans —

Researchers at University of California, San Diego School of Medicine used algae as a mini-factory to produce a malaria parasite protein. The algae-produced protein, paired with an immune-boosting cocktail suitable for use in humans, generated antibodies in mice that nearly eliminated mosquito infection by the malaria parasite. The method, published Feb. 17 by Infection and Immunity, is the newest attempt to develop a vaccine that prevents transmission of the malaria parasite from host to mosquito. … Read the full story from the UC San Diego Newsroom


Dr. Joseph VinetzStudy senior author Joseph Vinetz, MD, is professor of medicine in the Division of Infectious Diseases.

Read article abstract

UC San Diego Biologists Produce Potential Malarial Vaccine from Algae

Biologists at the University of California, San Diego have succeeded in engineering algae to produce potential candidates for a vaccine that would prevent transmission of the parasite that causes malaria, an achievement that could pave the way for the development of an inexpensive way to protect billions of people from one of the world’s most prevalent and debilitating diseases. Initial proof-of-principle experiments suggest that such a vaccine could prevent malaria transmission…. Read the full story from the UCSD Newsroom


Dr. Joseph VinetzThe research team included Dr. Joseph Vinetz, pictured at left, and Dr. Fengwu Li from the Department of Medicine.Dr. Vinetz is professor of medicine in the Division of Infectious Diseases and program director of the Peruvian/Brazilian Amazon Center of Excellence in Malaria Research.

Fengwu Li is an associate project scientist in Dr. Vinetz’s laboratory.

Read the study report in PLoS One (Open access article)

Article citation: Gregory JA, Li F, Tomosada LM, Cox CJ, Topol AB, et al. (2012) Algae-Produced Pfs25 Elicits Antibodies That Inhibit Malaria Transmission. PLoS ONE 7(5): e37179. doi:10.1371/journal.pone.0037179