Researchers Find Key Player in Diabetic Kidney Disease Through Power of Metabolomics

Tapping the potential of metabolomics, an emerging field focused on the chemical processes of metabolism, researchers at University of California, San Diego School of Medicine have identified a new and pivotal player in diabetic kidney disease.

The study, published online July 22 in the Journal of the American Society of Nephrology, also clarifies a central mechanism of action in diabetic kidney disease that is generating considerable excitement among researchers and the biopharmaceutical community. The mechanism, involving the NADPH (nicotinamide adenine dinucleotide phosphate) oxidase (NOX) proteins, NOX1 and NOX4, is now the subject of a phase II clinical trial for the treatment of diabetic kidney disease. … Read the Full Story from the UC San Diego News Center

Kumar Sharma, MD, FAHASenior author of the study report is Kumar Sharma, MD, FAHA, professor of medicine in the Division of Nephrology and director of the Center for Renal Translational Medicine at UC San Diego School of Medicine.

Read the study report in the Journal of the American Society of Nephrology  (UC San Diego Only)

Tumor-Activated Protein Promotes Cancer Spread

Researchers at the University of California, San Diego School of Medicine and UC San Diego Moores Cancer Center report that cancers physically alter cells in the lymphatic system – a network of vessels that transports and stores immune cells throughout the body – to promote the spread of disease, a process called metastasis.  … Read the full story from the UCSD Newsroom

Dr. Judith VarnerJudith Varner, PhD, is senior author of the study report. She is professor of medicine in the Division of Hematology-Oncology and an investigator in the Solid Tumor Therapeutics Program at the UC San Diego Moores Cancer Center.

Citation for the study report:
PI3Kα activates integrin α4β1 to establish a metastatic niche in lymph nodes. Barbara Garmy-Susini, Christie J. Avraamides, Jay S. Desgrosellier, Michael C. Schmid, Philippe Foubert, Lesley G. Ellies, Andrew M. Lowy, Sarah L. Blair, Scott R. Vandenberg, Brian Datnow, Huan-You Wang, David A. Cheresh, and Judith Varner. PNAS 2013 ; published ahead of print May 13, 2013, doi:10.1073/pnas.1219603110  |  Abstract  |  Read the article (PDF) (UCSD only)

Identifying Heart Failure When Minutes Count

News Feature from the UC San Diego Health System Newsroom

Identifying Heart Failure When Minutes Count
A profile of Dr. Alan S. Maisel
Director of the Coronary Care Unit and Heart Failure Program
Veterans Affairs San Diego Healthcare System
by Scott LaFee

The ambulance arrives: lights flashing, siren blaring. Paramedics rush their patient – a 55-year-old male complaining of severe shortness of breath – into the hospital’s emergency room. He may be a case of life-threatening heart failure, but many non-cardiac diseases have similar symptoms. Confirmation is critical. It will determine what happens next; how the patient will be treated.”… Read the full profile from the UC San Diego Health System newsroom