Richard D. Kolodner Elected to Institute of Medicine

University of California, San Diego School of Medicine researchers Joseph G. Gleeson, MD, Howard Hughes Medical Institute investigator and professor of neurosciences and pediatrics, and Richard D. Kolodner, PhD, professor of medicine and Ludwig Cancer Research scientist, have been named new members of the Institute of Medicine (IOM), considered among the highest honors in the fields of health and medicine. … Read the full story from the UC San Diego News Center


Dr. Richard KolodnerGeneticist and biochemist Richard D. Kolodner, PhD, is a distinguished professor in the departments of medicine (Division of Hematology-Oncology) and cellular and molecular medicine at UC San Diego.

Kolodner co-leads the Laboratory of Cancer Genetics in the San Diego branch of the Ludwig Institute for Cancer Research, which is located at UC San Diego.

At the UC San Diego Moores Cancer Center, he co-leads the Cancer Genomes and Networks research program with Trey Ideker, PhD, and is a member of the faculty of the Cancer Therapeutics Training (CT2) Program.

He is also a member of the Institute for Genomic Medicine and the Biomedical Sciences graduate program.

Kolodner was elected to the National Academy of Sciences in 2000 and the American Academy of Arts and Sciences in 2008. His election to the Institute of Medicine brings to 10 the number of Department of Medicine faculty members who are members of the institute.

See other UC San Diego news stories about Dr. Kolodner and his work.

New Way of Fighting High Cholesterol Upends Assumptions

Atherosclerosis – the hardening of arteries that is a primary cause of cardiovascular disease and death – has long been presumed to be the fateful consequence of complicated interactions between overabundant cholesterol and resulting inflammation in the heart and blood vessels. … Read the full story from the UCSD Newsroom


Christopher K. GlassSenior author of the study report is Christopher K. Glass, MD, PhD, pictured at left, professor in the Departments of Medicine and Cellular and Molecular Medicine.

The other Department of Medicine coauthors on the study report are Andrew C. Li, MD, PhD, assistant professor of medicine in the Division of Endocrinology and Metabolism; Sotirios Tsimikas, MD, FACC, professor of clinical medicine in the Division of Cardiovascular Medicine; and Oswald Quehenberger, PhD, professor of medicine in the Division of Endocrinology and Metabolism.

Read the report of the study in Cell (full text UCSD only)

Citation of study report: Spann NJ, Garmire LX, McDonald JG, Myers DS, Milne SB, Shibata N, Reichart D, Fox JN, Shaked I, Heudobler D, Raetz CRH, Wang EW, Kelly SL, Sullards MC, Murphy RC, Merrill AH Jr, Brown HA, Dennis EA, Li AC, Ley K, Tsimikas S, Fahy E, Subramaniam S, Quehenberger O, Russell DW, Glass CK. Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell 151(1):138-152, 2012. http://dx.doi.org/10.1016/j.cell.2012.06.054

Roche Funds Drug Discovery Projects at UC San Diego

The new UC San Diego-Roche Extending Innovation Network (EIN) program has been launched with selection of its first three research projects at the University of California, San Diego School of Medicine. The UC San Diego-Roche EIN program, which was formalized in June 2011, aims to accelerate the discovery of new drug therapies through research innovation at the interface of industry and academia. The program is slated to grow in the coming years as additional rounds of proposals are solicited. … Read the full story from the UCSD Newsroom

M. Geoffrey Rosenfeld, MD
M. Geoffrey Rosenfeld, MD (pictured above), is a co-investigator with Xiang-Dong Fu, PhD, on one of the three UC San Diego-Roche EIN-funded projects, in which the investigators will use genomic and RNA-based approaches to identify new drug targets.

Dr. Rosenfeld is Professor of Medicine in the Division of Endocrinology and Metabolism and a professor of the Howard Hughes Medical Institute. Dr. Fu is Professor of Cellular and Molecular Medicine and a member of the Institute for Genomic Medicine.

Dr. Pradipta Ghosh Receives Burroughs Wellcome Fund Career Award

Dr. Pradipta GhoshDepartment of Medicine physician-scientist Dr. Pradipta Ghosh is one of only five researchers in the United States to receive a Burroughs Wellcome Fund Career Award for Medical Scientists this year.The $700,000, 5-year award honors Dr. Ghosh for her innovative investigation of G protein activity in the development and spread of cancerous tumors.

It’s a research project that she developed during her training here at UC San Diego. The Burroughs Wellcome award will support her as she continues this work as an independent faculty investigator.

Pradipta Ghosh, M.D., is Assistant Professor of Medicine in the Division of Gastroenterology.

Dr. Ghosh joined the faculty of the Division of Gastroenterology after she completed her subspecialty training last fall.

Read the full story from the UC San Diego News Center

She is a graduate of the UC San Diego Internal Medicine Residency Training Program, the Gastroenterology Fellowship Training Program and the Department of Medicine Physician-Scientist Training Program.In her laboratory, Dr. Ghosh investigates the cell biology of signal transduction to find new ways to understand and block the development and spread of cancer and other diseases.

Dr Ghosh obtained her postdoctoral training in the laboratory of Marilyn G. Farquhar, Ph.D., Distinguished Professor in the Department of Cellular and Molecular Medicine and Professor in the Department of Pathology.

The Burroughs Wellcome Career Award for Medical Scientists was established in 2007 to support new physician-scientists as they complete their training and establish their careers as independent academic investigators.

Also honored with a Burroughs Wellcome Fund Career Award this year were UC San Diego’s Quyen T. Nguyen, M.D., Ph.D., Assistant Professor of Surgery in the Division of Otolaryngology, and previous UCSD Department of Medicine research resident Chester Drum, M.D., Ph.D., currently on faculty at Harvard University School of Medicine.