Researchers Illuminate Key Role of NOX Proteins in Liver Disease

Study adds credence to new treatment approach now in clinical trials —

Researchers at the University of California, San Diego School of Medicine have demonstrated a direct connection between two signaling proteins and liver fibrosis, a scarring process underlying chronic liver disease, the 12th leading cause of death in the United States.

The finding adds further credence to a current pharmaceutical effort to create new treatments for diabetic nephropathy, liver fibrosis and other progressive fibrotic and inflammatory diseases, based on blocking these two molecules, both members of the NADPH (nicotinamide adenine dinucleotide phosphate) oxidase (NOX) family of proteins. … Read the Full Story from the UC San Diego News Center


David A. Brenner, MDSenior author of the study report is David A. Brenner, MD, vice chancellor for health sciences, dean of UC San Diego School of Medicine and professor in the Division of Gastroenterology. The report was published online in PLOS ONE on July 29.

Read the article (open access)

UC San Diego-Human Longevity Inc. Agreement Seeks to Accelerate Medical Science

Thousands of patient genomes expected to fuel diverse medical research, beginning with cancer

The new collaborative research agreement between Human Longevity Inc. (HLI) and the University of California, San Diego, announced today, represents a significant and necessary step in efforts to research and translate the potential of the human genome into novel and real treatments and therapies able to change and improve the human condition.

“This agreement brings together the resources of two entities that, in combination, may ultimately help improve countless lives,” said David A. Brenner, MD, vice chancellor of health sciences at UC San Diego and dean of the UC San Diego School of Medicine. “HLI aims to bring leading-edge thinking in genomics technologies. UC San Diego boasts some of the world’s finest researchers and physicians working at places like the Moores Cancer Center. Together, we will collaborate to marshal the people, the tools and the resources to really make a difference in human health.” … Read the full story from the UC San Diego News Center

Dr. David Brenner Speaking at Grand Rounds March 13

David A. Brenner, MD Speaking at Medicine Grand Rounds on March 13 is Dr. David A. Brenner, vice chancellor for health sciences, dean of the UCSD School of Medicine and professor of medicine in the Division of Gastroenterology.

A physician-scientist, Brenner is widely respected for his translational research in liver disease. He will speak at Grand Rounds on new approaches to therapy for fibrosis.

Brenner is a member of numerous honorific societies including the American Society of Clinical Investigation, the American College of Physicians and the Association of American Physicians, of which he is immediate Past President. Last year, he was elected to the Institute of Medicine.

UC San Diego press releases about his recent research:

Read Dr. Brenner’s School of Medicine Biography

About Medicine Grand Rounds

UCSD’s Medicine Grand Rounds is held weekly on Wednesday mornings, 7:30 – 8:30 a.m., in the Liebow Auditorium, second floor, Biomedical Sciences Building on the UCSD School of Medicine Campus. There is a hiatus in summer.

To see this year’s schedule and find video viewing information, visit the Medicine Grand Rounds page on the Department of Medicine website.