New Cellular Pathway Triggering Allergic Asthma Response Identified

With molecular target found comes possibility of new therapies for millions of Americans —

Researchers at the University of California, San Diego School of Medicine, with collaborators in Korea and Scotland, have identified a novel signaling pathway critical to the immune response of cells associated with the initiation of allergic asthma. The discovery, they say, could point the way to new therapies that suppress the inflammatory allergic response, offering potential relief to millions of Americans with the chronic lung condition and potentially other allergic diseases.

The results are published in the January 19 online Early Edition of the Proceedings of the National Academy of Sciences. . … Read the full story from the UC San Diego Newsroom


Dr. Eyal Raz

Dr. Eyal Raz

Principal investigator of the study is Eyal Raz, MD, professor of medicine in the Division of Rheumatology, Allergy and Immunology, whose research focuses on the fundamentals of innate immunity.

First author of the report is Jihyung Lee, PhD, a postdoctoral fellow in the Raz lab.

Coauthors include David H. Broide, MB, ChB, professor of medicine and director of the division’s National Institute of Allergy and Infectious Diseases-funded T32 training program in molecular and cell biology of allergy; Paul Insel, MD, professor of pharmacology and medicine; Maripat Corr, MD, professor of medicine; project scientist Jongdae Lee, PhD; all in the Division of Rheumatology, Allergy and Immunology; and Nicholas Webster, PhD, professor of medicine and chief of the UC San Diego Division of Endocrinology and Metabolism.

View article abstract

Tobacco Smoke Causes Lung Inflammation, Promotes Lung Cancer Growth

Dr. David H. Broide, Professor of Medicine in the Division of Rheumatology, Allergy, and Immunology, contributed to the study reported in the UCSD Newsroom story, “Tobacco Smoke Causes Lung Inflammation, Promotes Lung Cancer Growth.”

Read the story from the UCSD Newsroom.

The story has run in a number of online publications including Medical News Today, ScienceDaily, Science Centric, and BusinessWeek.