Single Dose Reverses Autism-like Symptoms in Mice

Old drug used for sleeping sickness may point to new treatment in humans

In a further test of a novel theory that suggests autism is the consequence of abnormal cell communication, researchers at the University of California, San Diego School of Medicine report that an almost century-old drug approved for treating sleeping sickness also restores normal cellular signaling in a mouse model of autism, reversing symptoms of the neurological disorder in animals that were the human biological age equivalent of 30 years old. … Read the full story from the UC San Diego Newsroom

Seema Sharma Aceves MD, PhD, Elected to American Society for Clinical Investigation

Dr. Seema S. AcevesUC San Diego pediatric allergy/immunology physician-scientist Seema Sharma Aceves, MD, PhD, has been elected to the American Society for Clinical Investigation (ASCI).

She was formally inducted into the Society in a ceremony at the ASCI annual meeting in Chicago on April 26.

“It is a true honor to be included in this distinguished group of translational research leaders,” Aceves said.

“Seema represents the best and the brightest among clinical investigators today,” said Gary S. Firestein, MD, who nominated her for the honor.

“Her remarkable progress understanding the causes of an unusual and very debilitating disease in children made a significant impact on their quality of life.”

Firestein is professor of medicine in the Division of Rheumatology, Allergy & Immunology, Dean of Translational Medicine, Associate Vice Chancellor of Translational Medicine and director of the Clinical and Translational Research Institute.

Aceves, a specialist in pediatric eosinophilic esophagitis (EoE), is associate professor of clinical medicine in the Division of Rheumatology, Allergy & Immunology and associate professor of pediatrics in the Division of Allergy-Immunology-Rheumatology.

In her research, she investigates the mechanisms of tissue remodeling in EoE, exploring the role of pro-inflammatory and pro-fibrotic molecules. Major support for her work comes from a National Institutes of Health R01 research grant and funding from the Department of Defense.  |  Read NIH grant abstract

Her clinical specialty is pediatric allergy (Rady Children’s Specialists of San Diego). She practices at Rady Children’s Hospital – San Diego, where she directs the Eosinophilic Gastrointestinal Disorders Clinic.

Aceves received all of her medical training at UC San Diego. After she earned her MD and PhD in the Medical Scientist Training Program, she completed her internship and residency in the Department of Pediatrics and her fellowship training in allergy and immunology in the Department of Medicine.

She is board certified in allergy/immunology and pediatric allergy/immunology.

She was named a Physician of Exceptional Excellence in the 2012-2013 “San Diego’s Top Doctors” survey from the San Diego County Medical Society and San Diego Magazine and listed as one of the nation’s top doctors on the 2012-2013 U.S.News & World Report “Top Doctors” List.