UC San Diego Health Researchers Join Pancreatic Cancer “Dream Team”

November 10, 2015

International effort will seek to develop and test new therapies for deadly malignancy —

In an effort to advance research on one of the deadliest forms of cancer, University of California, San Diego School of Medicine researchers Andrew Lowy, MD, and Tannishtha Reya, PhD, have been recruited for their expertise in preclinical modeling, clinical trials and stem cell biology to join a “dream team” of international pancreatic cancer researchers.

The three-year, $12-million effort, sponsored by Stand Up To Cancer, Cancer Research UK and The Lustgarten Foundation, will pursue a three-pronged strategy to better understand and reset so-called “super-enhancers” that may be abnormally active in pancreatic tumors. Super-enhancers are bits of DNA that can cause over-expression of genetic signals, fueling cancer cell growth. … Read the full story from the UC San Diego Newsroom


Tannishtha Reya, PhD, is Professor of Pharmacology in the Skaggs School of Pharmacy and Pharmaceutical Sciences and Professor of Medicine in the University of California, San Diego School of Medicine.

Split Decision: Stem Cell Signal Linked With Cancer Growth

Researchers at the University of California, San Diego School of Medicine have identified a protein critical to hematopoietic stem cell function and blood formation. The finding has potential as a new target for treating leukemia because cancer stem cells rely upon the same protein to regulate and sustain their growth. … Read the full story from the UC San Diego News Center


Dr. Gary HardimanGary Hardiman, PhD, associate professor in the Division of Endocrinology and Metabolism, is an investigator on the study.

Citation for the study report in Nature Genetics: Bryan Zimdahl, Takahiro Ito, Allen Blevins, Jeevisha Bajaj, Takaaki Konuma, Joi Weeks, Claire S Koechlein, Hyog Young Kwon, Omead Arami, David Rizzieri, H Elizabeth Broome, Charles Chuah, Vivian G Oehler, Roman Sasik, Gary Hardiman & Tannishtha Reya. Nature Medicine advance online publication, 02 February 2014 (doi:10.1038/ng.2889). Summary | Full text (UCSD only)