Protein That Protects During Stress Sheds Light on How Diabetes Drug Prevents Tumors

Researchers at University of California San Diego School of Medicine have identified a previously unknown mechanism that helps fortify the structure and tight junctions between epithelial cells — a basic cell type that lines various body cavities and organs throughout the body, forming a protective barrier against toxins, pathogens and inflammatory triggers. Breaches of this barrier can provoke organ dysfunction and development of tumors.

The findings, published online in the current issue of eLife by senior author Pradipta Ghosh, MD … Read the Full Story from the UC San Diego Newsroom


Dr. Pradipta Ghosh

Pradipta Ghosh, MD

Pradipta Ghosh, MD, MBBS, is Professor of Medicine in the Division of Gastroenterology.

She is a graduate of the UC San Diego Internal Medicine Residency Training Program, the Gastroenterology Fellowship Training Program and the Department of Medicine Physician-Scientist Training Program.

Insulin Resistance Reversed by Removal of Protein

By removing the protein galectin-3 (Gal3), a team of investigators led by University of California School of Medicine researchers were able to reverse diabetic insulin resistance and glucose intolerance in mouse models of obesity and diabetes. … Read the Full Story from the UC San Diego Newsroom


Dr. Jerrold Olefsky

Dr. Jerrold Olefsky

Dr. Jerrold Olefsky, Professor of Medicine in the Division of Endocrinology and Metabolism in the School of Medicine at UC San Diego, is principal investigator of this international study.

Read the Study Report (Full Content, UCSD Only)

See Dr. Olefsky’s Research Profile

New Institute for Diabetes and Metabolic Health Debuts at UC San Diego

Expansive effort will encompass both research and treatment of major national health issue —

The University of California San Diego School of Medicine has launched the Institute for Diabetes and Metabolic Health (IDMH), a new cross-disciplinary, collaborative effort to address one of the nation’s leading public health threats.

“Diabetes and other metabolic disorders pose an immense, perhaps unprecedented, health threat to virtually everyone,” said Alan Saltiel, PhD, IDMH director and one of the nation’s leaders in the study of metabolic disorders. “Tens of millions of Americans of all ages are already afflicted so the imperative is great to understand better these chronic, life-threatening conditions and find new ways to treat and prevent them.” … Read the Full Story from the UC San Diego Newsroom


Alan Saltiel, PhD

Alan Saltiel, PhD

IDMH Director Alan Saltiel, PhD, is Professor of Medicine in the Division of Endocrinology and Metabolism.

— Read his UCSD Profile
— Visit the Saltiel Laboratory website
— Visit the Institute for Diabetes and Metabolic Health website

New UC San Diego Center Will Focus on Heart Health Among Latinas

Researchers at the University of California, San Diego School of Medicine have launched a new four-year, $3.7 million multidisciplinary research center to investigate the relationship between sedentary behavior and cardiovascular risk factors in Latinas, who have a disproportionately higher chance of developing heart disease than the general population.

The study is part of a new Strategically Focused Research Network created and funded by the American Heart Association (AHA). … Read the Full Story from the UC San Diego Newsroom


Dorothy Sears, PhD

Dorothy Sears, PhD

Within the multidisciplinary research center, Dorothy Sears, PhD, Associate Professor of Medicine in the Division of Endocrinology & Metabolism, will conduct studies to find and characterize biomarkers of cardiovascular disease risk associated with sedentary behavior.

UC San Diego Endocrinologists Team with Pharmacists to Offer Diabetes “Tune Up” Clinic

Dr. Steven Edelman

Dr. Steven Edelman

Department of Medicine endocrinologists Steven V. Edelman, MD, (left) and Robert R. Henry, MD (below right), collaborate with Candis Morello, Pharm D, and students in the Skaggs School of Pharmacy and Pharmaceutical Sciences to offer a six-month Diabetes Intensive Medical Management (DIMM) “tune up” clinic for patients with complex cases of diabetes at the VA San Diego Healthcare System.

Dr. Robert Henry

Dr. Robert Henry

At each visit, a patient receives an hour of personalized attention to medication management, diet, exercise, controlling blood sugar levels and other necessities that may be involved in a complex case of diabetes.

The aim is to achieve glycemic control within the six-month period of the “tune up” clinic..

In a preliminary study, Drs. Morello, Evans, Henry and coworkers have assessed the outcomes of the clinic, and the findings indicate that this pharmacist-endocrinologist collaborative approach is effective.  |  Read the Study Abstract in the January 2016 issue of Annals of Pharmacotherapy  |  Read the full story from the UC San Diego Newsroom

Steven V. Edelman, MD, Clinical Professor in the Department of Medicine, directs the Diabetes Care Clinic at VA San Diego Healthcare System (VASDHS) and is an investigator in the VA Center for Metabolic Research. He is founder and director of Taking Control of Your Diabetes, a non-profit diabetes education organization. He conducts research focusing on developing and evaluating new treatments for type 1 and type 2 diabetes.

Robert R. Henry, MD, Professor in the Department of Medicine, is Chief of the VA Center for Metabolic Research and Chief of the Section of Endocrinology, Metabolism and Diabetes at VASDHS. In his research, he investigates the etiology, treatment, and prevention of obesity and type 2 diabetes.

Dr. Morello is Professor of Clinical Pharmacy and Associate Dean for Student Affairs at Skaggs School of Pharmacy and Pharmaceutical Sciences.

The study report was published online in November, 2015, and in print in January, 2016.

New Findings on Fat Cell Metabolism Could Lead to New Approaches for Treating Diabetes and Obesity

November 17, 2015

Researchers at the University of California, San Diego report new insights into what nutrients fat cells metabolize to make fatty acids. The findings pave the way for understanding potential irregularities in fat cell metabolism that occur in patients with diabetes and obesity and could lead to new treatments for these conditions. The researchers published their findings online in the Nov. 16 issue of Nature Chemical Biology…. Read the full story from the UC San Diego Newsroom

Spotting the Earliest Signs of Type 1 Diabetic Kidney Disease

JDRF network grant to fund study to find new types of diagnostic markers —

In an effort to pinpoint the earliest signs of diabetic kidney disease, researchers at University of California, San Diego School of Medicine are leading a multi-institutional international effort dedicated to finding a new breed of disease indicators.

The study, funded by a $2.5 million JDRF (formerly known as the Juvenile Diabetes Research Foundation) grant, will tap the potential of three emerging “omics” sciences to discover new ways to determine which patients are most likely to develop diabetic kidney disease. Samples from more than 2,000 type 1 diabetes patients, collected over a period of years by several medical centers around the world, will be used in the analyses. …Read the full story from the UC San Diego Newsroom


Kumar Sharma, MD, FAHAPrincipal investigator of the study is Kumar Sharma, MD, FAHA, Professor of Medicine in the Division of Nephrology. He directs the Center for Renal Translational Medicine and the Institute of Metabolomic Medicine in UC San Diego School of Medicine.

Researchers Find Key Player in Diabetic Kidney Disease Through Power of Metabolomics

Tapping the potential of metabolomics, an emerging field focused on the chemical processes of metabolism, researchers at University of California, San Diego School of Medicine have identified a new and pivotal player in diabetic kidney disease.

The study, published online July 22 in the Journal of the American Society of Nephrology, also clarifies a central mechanism of action in diabetic kidney disease that is generating considerable excitement among researchers and the biopharmaceutical community. The mechanism, involving the NADPH (nicotinamide adenine dinucleotide phosphate) oxidase (NOX) proteins, NOX1 and NOX4, is now the subject of a phase II clinical trial for the treatment of diabetic kidney disease. … Read the Full Story from the UC San Diego News Center


Kumar Sharma, MD, FAHASenior author of the study report is Kumar Sharma, MD, FAHA, professor of medicine in the Division of Nephrology and director of the Center for Renal Translational Medicine at UC San Diego School of Medicine.

Read the study report in the Journal of the American Society of Nephrology  (UC San Diego Only)

Leading Metabolics Researcher Joins UC San Diego School of Medicine

Alan Saltiel will head unified effort to create comprehensive diabetes center —

Alan R. Saltiel, PhD, whose studies of the hormone insulin have helped drive research of obesity, diabetes and other metabolic disorders across the nation, is joining University of California, San Diego School of Medicine as professor and director of a new Comprehensive Diabetes Center.

Saltiel, who most recently served as director of the Life Sciences Institute at University of Michigan, will bring together and expand UC San Diego’s diverse programs to better understand and treat diabetes and other metabolic disorders. … Read the full story from the UC San Diego Newsroom


Dr. Saltiel joins the Department of Medicine as professor in the Division of Endocrinology and Metabolism.

Internal Medicine Resident Drs. Julie Chen and Darrin Wong Present Research at Department of Medicine Grand Rounds

Drs. Darrin Wong and Julie Chen at Medicine Grand Rounds.

Drs. Darrin Wong and Julie Chen at Medicine Grand Rounds.

On June 3, 2015, Drs. Julie Chen and Darrin Wong presented their research at Department of Medicine Grand Rounds.

The subject of Dr. Chen’s research was “Failure to Adjust Diabetes Medications at Discharge for Hospitalized Patients with Poorly Controlled Diabetes.”

Dr. Chen worked with members of the faculty in the Division of Endocrinology and Metabolism, including Drs. Robert El-Kareh and Kristen Kulasa as well as Dr. Pedro Ramos from the Division of Hospital Medicine.

Dr. Wong presented his research on the topic, “Right Ventricular Dyssynchrony in CTEPH.” He worked with Dr. Daniel Blanchard from the Division of Cardiovascular Medicine.

Dr. Wong presenting background information about echocardiography.

Dr. Wong presenting background information about echocardiography.

Drs. Chen and Wong won their places at Medicine Grand Rounds when they were chosen for their admirable research achievements at the UC San Diego Annual Internal Medicine Resident Research Symposium on May 7.

The other research symposium winners were Drs. Satya Das, Noel Lee, Michele Pham and Kevin Shah. Drs. Das, Lee, and Pham will present their research at Medicine Grand Rounds on June 10.

Dr. Shah presented his research, along with fellow resident Dr. Nick Marston, on the topic, “Serial Sampling of Copeptin Levels Improves Diagnosis and Risk Stratification in Patients Presenting with Chest Pain: Results from the CHOPIN Trial” last June.

2015 Resident Research Symposium Winners

Research winners at last month’s Annual Internal Medicine Resident Research Symposium. Left to right: Drs. Shah, Lee, Das, Chen, Pham and Wong.