Herpes Virus Exploits Immune Response to Bolster Infection

Researchers at the University of California, San Diego School of Medicine and colleagues report that the herpes simplex virus type-1 (HSV-1), which affects an estimated 50 to 80 percent of all American adults, exploits an immune system receptor to boost its infectivity and ability to cause disease. … Read the full story from the UCSD Newsroom


Dr. Richard Gallo

Dr. Richard Gallo

Richard L. Gallo, MD, PhD, left, is principal investigator of the study, which is reported in the online-only journal Nature Communications.

Gallo is professor of medicine and chief of the Division of Dermatology.

Citation for the study report:  Daniel T. MacLeod, Teruaki Nakatsuji, Kenshi Yamasaki, Lester Kobzik & Richard L. Gallo. HSV-1 exploits the innate immune scavenger receptor MARCO to enhance epithelial adsorption and infection. Nature Communications 4, Article number: 1963. doi:10.1038/ncomms2963. Published 06 June 2013.  |  Abstract

More Information:

Protein May Be Key to Psoriasis and Wound Care

Psoriasis is an autoimmune disorder in which skin cells proliferate out of control. For some hard-to-heal wounds, the problem is just the opposite: Restorative skin cells don’t grow well or fast enough. In a paper published in the June 21, 2012 issue of Immunity, researchers at the University of California, San Diego School of Medicine describe a molecule that may lead to new treatments for both problems. … Read the full story from the UCSD Newsroom


Dr. Richard GalloThe principal investigator of this collaborative study is Richard L. Gallo, MD, PhD, professor of medicine and chief of the Division of Dermatology at UC San Diego.

The other Department of Medicine co-authors are Tissa Hata, MD, professor of medicine, Clinical Service Chief for Dermatology at the Perlman Ambulatory Care Center and Director of the UCSD Dermatology Clinical Trials Unit; Beda Mühleisen, MD; and Paul Kotol.

More information:

  • Read the article summary in Immunity.
  • Citation: Yuping Lai, Dongqing Li, Changwei Li, Beda Muehleisen, Katherine A. Radek, Hyun Jeong Park, Ziwei Jiang, Zhiheng Li, Hu Lei, Yanchun Quan, Tian Zhang, Yelin Wu, Paul Kotol, Shin Morizane, Tissa R. Hata, Keiji Iwatsuki, Ce Tang, Richard L. Gallo, The Antimicrobial Protein REG3A Regulates Keratinocyte Proliferation and Differentiation after Skin Injury, Immunity, Available online 21 June 2012, ISSN 1074-7613, 10.1016/j.immuni.2012.04.010.
  • Dr. Gallo’s laboratory website

Hormone Plays Surprise Role in Fighting Skin Infections

Boosts immune response when vitamin D levels are low

Antimicrobial peptides (AMPs) are molecules produced in the skin to fend off infection-causing microbes. Vitamin D has been credited with a role in their production and in the body’s overall immune response, but scientists at the University of California, San Diego School of Medicine say a hormone previously associated only with maintaining calcium homeostasis and bone health is also critical, boosting AMP expression when dietary vitamin D levels are inadequate. … Read the full story from the UCSD Newsroom


Dr. Richard GalloThe report comes from Dr. Richard Gallo (pictured at left) and colleagues at UC San Diego, the Veterans Affairs San Diego Healthcare System, and UC San Francisco.

Richard L. Gallo, MD, PhD, is professor of medicine and chief of the UCSD Division of Dermatology and the Dermatology section of the Veterans Affairs San Diego Healthcare System.

The Department of Medicine coauthors of the study are first author Beda Muehleisen, Carlos Aguilera, and George L. Sen, Division of Dermatology, UC San Diego; Douglas W. Burton, Veterans Administration San Diego Healthcare System; and Leonard J. Deftos, MD, JD, LLM, Veterans Administration San Diego Healthcare System and Division of Endocrinology and Metabolism, Department of Medicine, UC San Diego.

More information:

  • Read the article in Science Translational Medicine.
    Citation: B. Muehleisen, D. D. Bikle, C. Aguilera, D. W. Burton, G. L. Sen, L. J. Deftos, R. L. Gallo, PTH/PTHrP and Vitamin D Control Antimicrobial Peptide Expression and Susceptibility to Bacterial Skin Infection. Sci. Transl. Med. 4, 135ra66 (2012). DOI:10.1126/scitranslmed.3003759
  • Visit Dr. Gallo’s Laboratory Website

Cholesterol-Lowering Statins Boost Bacteria-Killing Cells

Widely prescribed for their cholesterol-lowering properties, recent clinical research indicates that statins can produce a second, significant health benefit: lowering the risk of severe bacterial infections such as pneumonia and sepsis… Read the full story from the UCSD Newsroom

Christopher K. Glass, M.D., Ph.D.

Department of Medicine coauthors on the published paper are Anna L. Kogen, Ph.D., Richard Gallo, M.D., Ph.D., Professor of Medicine and Pediatrics and Chief of the Division of Dermatology; and corresponding author Christopher K. Glass, M.D., Ph.D. (pictured above), Professor of Medicine in the Division of Endocrinology and Metabolism and Professor of Cellular and Molecular Medicine.

Read the published study (PDF).

Moving Ahead With the Leadership of Interim Chair Wolfgang H. Dillmann, M.D.

Wolfgang Dillmann, MDWolfgang H. Dillmann, MD, a respected division chief and internationally recognized physician-scientist, assumes leadership of the Department of Medicine this week as Dr. Ken Kaushansky departs for his new position as Senior Vice President for Health Sciences and Dean of the School of Medicine at Stony Brook University in New York.

“Wolf has made major contributions to the Department of Medicine for decades, in the realms of science, teaching and clinical care,” said Dr. Kaushansky.

“Now, by taking on the challenging role as interim Chair, he will make even greater contributions to the students, residents, fellows and faculty who call the department home.”

Dr. Dillmann, Professor of Medicine and Chief of the Division of Endocrinology and Metabolism, has served the Department for many years in positions on the Finance Committee and the Space Committee.

Dr. Joe Witztum, Professor of Medicine and Dr Dillmann’s longtime colleague in the division, described him as a dedicated and thoughtful leader, a superb clinician, and a true physician-scientist. “I’m not surprised that he was asked to be Interim Chair,” he said.

Dr. Tom Savides Named Executive Vice Chair

New positions in the Department of Medicine leadership team will support Dr. Dillmann in his interim role. Dr. Tom Savides, Professor of Clinical Medicine and Interim Chief of the Division of Gastroenterology, will serve as Executive Vice Chair.

Dr. Savides also holds the positions of Clinical Service Chief for Gastroenterology, Director of the Gastroenterology Fellowship Program, and Director of Advanced GI Endoscopy.

Dr. Richard Gallo, Professor of Medicine and Pediatrics and Chief of the Division of Dermatology, will serve as Vice Chair for Laboratory Research and co-chair, with Dr. Robert Schooley, of the department’s Space Committee.

Dr. Schooley, Professor of Medicine and Chief of the Division of Infectious Diseases, will continue as Vice Chair for Academic Affairs.

As before, Drs. Elaine Muchmore, Dan Bouland, Francis Gabbai and Ravi Mehta will serve as the vice chairs for Education, Clinical Operations, VASDHS Affairs, and Clinical Research, respectively. Maureen O’Connor is Vice Chair for Administration.

About Dr. Dillmann

“Wolf is an old-fashioned physician-scientist,” said Dr. Witztum, who joined the faculty within months of Dr. Dillmann in 1979. “In the old days, we used to talk about the ‘triple threat’ – physician, scientist, and teacher. It’s hard to do all three, particularly these days, and Wolf still really does it well.”

In his clinical activities, Dr. Dillmann specializes in endocrine diseases, especially thyroid disease. His research activities are directed at endocrine and metabolic influence on cardiovascular function.

Over the years, he has maintained a deep involvement in clinical work despite the expansion in his other roles. “He’s a superb endocrinologist and internal medicine doctor,” Dr. Witztum said.

“He’s dedicated to providing good clinical services,” he said. “He works very hard to develop clinical programs, particularly for the care of diabetic and metabolic syndrome patients.”

In recent months, Dr. Dillmann has led the division through a successful recertification of the Endocrine Fellowship Training Program. He is an active teacher in the Department of Medicine’s core courses in the School of Medicine and he serves as mentor for postdoctoral fellows and medical students.

Dr. Dillmann’s research focused initially on thyroid disease and its effects on heart function. His work has expanded in recent years to examine the biochemical and cellular properties of heart cells and the ways in which they are affected by thyroid hormone and glucose metabolism.

“He has become an international expert on cardiac metabolism in general,” Dr. Witztum said. “His studies are of interest not only to endocrinologists but also to cardiologists who are interested in the basic mechanisms by which the heart works.”

Dr. Dillmann is a member of the Diabetes and Endocrinology Research Center (DERC), the Institute of Engineering in Medicine, and the Cardiac Mechanics Research Group at UCSD.

He serves as reviewer for a number of major scientific journals including the Journal of Clinical Investigation, Endocrinology, American Journal of Physiology, the Journal of Biological Chemistry, Circulation, and Circulation Research.

View Dr. Dillmann’s list of publications (PubMed)

Dr. Dillmann was born in Germany. After he received his MD degree from the University of Munich in 1970, he came to the United States to do his medical internship at City Hospital Center, Elmhurst, Mt. Sinai Hospital in New York City.

He completed his residency training in 1972 and his endocrinology and metabolism fellowship training in 1975 at Albert Einstein College of Medicine in Bronx, New York. After a year as Assistant Professor of Medicine there, he moved to the University of Minnesota, where he held the position of Assistant Professor of Medicine from 1976 through 1978.

In 1979, Dr. Dillmann joined the UC San Diego School of Medicine faculty as Assistant Professor in the Division of Endocrinology and Metabolism. He was promoted to Associate Professor in 1981 and to Professor in 1987. In 2005, he became chief of the division.

He is a member of the American Society for Clinical Investigation and the Association of American Physicians.