Dr. Christopher K. Glass Among Three UC San Diego Researchers Elected to National Academy of Medicine

Ferrara, Glass and Malinow join premier advisory group on national medical and health issues —

The National Academy of Medicine (NAM) announced today the election of three new members from University of California, San Diego School of Medicine: Napoleone Ferrara, MD; Christopher K. Glass, MD, PhD; and Roberto Malinow, MD, PhD. Election to NAM is considered among the highest honors in the fields of health and medicine. …Read the full story from the UC San Diego Newsroom


Christopher K. Glass, MD, PhDChristopher K. Glass, MD, PhD, is Professor of Cellular and Molecular Medicine and Professor of Medicine in the Division of Endocrinology and Metabolism.

Glass Lab Website

Leading Metabolics Researcher Joins UC San Diego School of Medicine

Alan Saltiel will head unified effort to create comprehensive diabetes center —

Alan R. Saltiel, PhD, whose studies of the hormone insulin have helped drive research of obesity, diabetes and other metabolic disorders across the nation, is joining University of California, San Diego School of Medicine as professor and director of a new Comprehensive Diabetes Center.

Saltiel, who most recently served as director of the Life Sciences Institute at University of Michigan, will bring together and expand UC San Diego’s diverse programs to better understand and treat diabetes and other metabolic disorders. … Read the full story from the UC San Diego Newsroom


Dr. Saltiel joins the Department of Medicine as professor in the Division of Endocrinology and Metabolism.

The Connection Between Oxygen and Diabetes

A lack of O2 in fat cells triggers inflammation and insulin resistance in obesity:

Researchers at the University of California, San Diego School of Medicine have, for the first time, described the sequence of early cellular responses to a high-fat diet, one that can result in obesity-induced insulin resistance and diabetes. The findings, published in the June 5 issue of Cell, also suggest potential molecular targets for preventing or reversing the process.

Dr. Jerrold Olefsky“We’ve described the etiology of obesity-related diabetes. We’ve pinpointed the steps, the way the whole thing happens,” said Jerrold M. Olefsky, MD (left), associate dean for Scientific Affairs and Distinguished Professor of Medicine at UC San Diego. “The research is in mice, but the evidence suggests that the processes are comparable in humans and these findings are important to not just understanding how diabetes begins, but how better to treat and prevent it … Read the full story from the UC San Diego Newsroom

UC San Diego Researcher to Lead First-of-Its-Kind NASA Identical Twins Study

Brinda Rana, a professor at the UC San Diego School of Medicine, has been awarded NASA funding to study fluid flows in the brains of identical twin astronauts—one of whom will spend a year in space, while the other is left on Earth. … Read the full story from the UC San Diego News Center

Christopher K. Glass and Clifford P. Kubiak Elected to the American Academy of Arts and Sciences

Two UC San Diego faculty members have been elected to the American Academy of Arts and Sciences, one of the nation’s most prestigious honorary societies, which includes accomplished leaders from academe, business, public affairs, the humanities and the arts.

Christopher K. Glass, a professor of medicine and of cellular and molecular medicine, and Clifford P. Kubiak, a distinguished professor of chemistry and biochemistry, join the 2014 class of academy members … Read the full story from the UC San Diego Newsroom

Split Decision: Stem Cell Signal Linked With Cancer Growth

Researchers at the University of California, San Diego School of Medicine have identified a protein critical to hematopoietic stem cell function and blood formation. The finding has potential as a new target for treating leukemia because cancer stem cells rely upon the same protein to regulate and sustain their growth. … Read the full story from the UC San Diego News Center


Dr. Gary HardimanGary Hardiman, PhD, associate professor in the Division of Endocrinology and Metabolism, is an investigator on the study.

Citation for the study report in Nature Genetics: Bryan Zimdahl, Takahiro Ito, Allen Blevins, Jeevisha Bajaj, Takaaki Konuma, Joi Weeks, Claire S Koechlein, Hyog Young Kwon, Omead Arami, David Rizzieri, H Elizabeth Broome, Charles Chuah, Vivian G Oehler, Roman Sasik, Gary Hardiman & Tannishtha Reya. Nature Medicine advance online publication, 02 February 2014 (doi:10.1038/ng.2889). Summary | Full text (UCSD only)

How DNA Damage Affects Golgi – The Cell’s Shipping Department

In studying the impact of DNA damage on the Golgi, a research team from the University of California, San Diego School of Medicine and the Ludwig Institute for Cancer Research have discovered a novel pathway activated by DNA damage, with important consequences for the body’s cellular response to chemotherapy. … Read the full story from the UC San Diego News Center


Dr. Seth FieldStudy principal investigator Seth J. Field, MD, PhD, is associate professor of medicine in the Division of Endocrinology and Metabolism.

Visit Dr. Field’s Laboratory Website

Citation for the study report in Cell: Suzette E. Farber-Katz, Holly C. Dippold, Matthew D. Buschman, Marshall C. Peterman, Mengke Xing, Christopher J. Noakes, John Tat, Michelle M. Ng, Juliati Rahajeng, David M. Cowan, Greg J. Fuchs, Huilin Zhou, Seth J. Field, DNA Damage Triggers Golgi Dispersal via DNA-PK and GOLPH3, Cell, Volume 156, Issue 3, 30 January 2014, Pages 413-427, ISSN 0092-8674. Summary | Full text (UCSD only)

The Role of “Master Regulators” in Gene Mutations and Disease

Researchers identify key proteins that help establish cell function

Researchers at the University of California, San Diego School of Medicine have developed a new way to parse and understand how special proteins called “master regulators” read the genome, and consequently turn genes on and off. … Read the full story from the UC San Diego News Center


Christopher K. Glass, MD, PhDThe principal investigator of the reported study is Christopher K. Glass, MD, PhD, professor of medicine in the Division of Endocrinology & Metabolism and professor of cellular and molecular medicine at UC San Diego.

He is on the faculty of the UC San Diego Institute for Genomic Medicine.

Visit the Glass Laboratory website.

Related UC San Diego news stories:

Checkup Diabetes: the Latest Research and Treatments from UC San Diego

News Feature from the UC San Diego Health System Newsroom

Checkup Diabetes: the latest research and treatments at UC San Diego

by Scott LaFee

Diabetes is a monumental public health issue, not just because millions of Americans have been diagnosed with the metabolic disease, but also for the many more millions who either remain undiagnosed or have signs suggesting they will likely become diabetic. .. Read the full news feature from the UC San Diego Health System newsroom

Enhancer RNAs Alter Gene Expression

New class of molecules may be key emerging “enhancer therapy”

In a pair of distinct but complementary papers, researchers at the University of California, San Diego School of Medicine and colleagues illuminate the functional importance of a relatively new class of RNA molecules. The work, published online this week in the journal Nature, suggests modulation of “enhancer-directed RNAs” or “eRNAs” could provide a new way to alter gene expression in living cells, perhaps affecting the development or pathology of many diseases. … Read the full story from the UCSD Newsroom


Christopher K. Glass

Christopher K. Glass, MD, PhD

Drs. Christopher Glass (left) and M. Geoffrey Rosenfeld (at right below) are the principal investigators of the two studies reported in Nature.

M. Geoffrey Rosenfeld, MD

M. Geoffrey Rosenfeld, MD

Christopher Glass, MD, PhD, is professor of medicine and cellular and molecular medicine. M. Geoffrey Rosenfeld is professor of medicine and biology and is a Howard Hughes Medical Institute professor.

Both are members of the Division of Endocrinology & Metabolism in the Department of Medicine.

Citations for the study reports:

Glass report:

Michael T. Y. Lam, Han Cho, Hanna P. Lesch, David Gosselin, Sven Heinz, Yumiko Tanaka-Oishi, Christopher Benner, Minna U. Kaikkonen, Aneeza S. Kim, Mika Kosaka, Cindy Y. Lee, Andy Watt, Tamar R. Grossman, Michael G. Rosenfeld, Ronald M. Evans & Christopher K. Glass.  Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription.  Nature (2013) doi:10.1038/nature12209. Published online 02 June 2013.  |   Full Text  (UCSD only)

Rosenfeld report:

Wenbo Li, Dimple Notani, Qi Ma, Bogdan Tanasa, Esperanza Nunez, Aaron Yun Chen, Daria Merkurjev, Jie Zhang, Kenneth Ohgi, Xiaoyuan Song, Soohwan Oh, Hong-Sook Kim, Christopher K. Glass & Michael G. Rosenfeld. Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation. Nature (2013) doi:10.1038/nature12210. Published online 02 June 2013.  |  Full text  (UCSD only)

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