Clinical Trial To Test Safety of Stem Cell-Derived Therapy for Type 1 Diabetes

UC San Diego is initial site for first-in-human testing of implanted cell therapy

Researchers at the University of California, San Diego School of Medicine, in partnership with ViaCyte, Inc., a San Diego-based biotechnology firm specializing in regenerative medicine, have launched the first-ever human Phase I/II clinical trial of a stem cell-derived therapy for patients with Type 1 diabetes. … Read the full story from the UCSD Newsroom


Principal investigator in the study is Robert R. Henry, MD, professor of medicine in the Division of Endocrinology and Metabolism at UC San Diego and chief of the Section of Endocrinology, Metabolism & Diabetes at the Veterans Affairs San Diego Healthcare System.

New Division Chief and Vice Chief of Endocrinology and Metabolism

Announced July 28, 2014, by Wolfgang H. Dillmann, MD, Helen M. Ranney Distinguished Professor and Chair of the Department of Medicine

Dr. Nicholas Webster

Nicholas Webster, PhD

I am pleased to announce that an internal review committee has selected Dr. Nick Webster as the new chief of the Division of Endocrinology and Metabolism in the Department of Medicine. Dr. Nai-Wen Chi has been selected to serve as vice chief.

Wolfgang H. Dillmann, MD

Wolfgang H. Dillmann, MD

I would like to express my gratitude to Dr. Nick Webster, who accepted the role of interim division chief after I stepped down in 2010. In leading the Division of Endocrinology and Metabolism for the past four years, Dr. Webster has done an important service for the division and the department.

Nick Webster, PhD, professor of medicine, is Associate Director for Shared Resources at the Moores Cancer Center and holds a joint appointment as a Senior Research Career Scientist at the VA San Diego Healthcare System. He is a highly respected researcher and thought leader in the field of endocrinology and metabolism.

Dr. Webster earned his B.A. and M.A. from Cambridge University and his Ph.D. from Stanford University.  After a post-doctoral fellowship at the CNRS in Strasbourg, France, he joined the UCSD faculty in the Division of Endocrinology and Metabolism in 1989 and was promoted to Professor in 2006.

Dr. Webster has been very active in service to the University and the Veterans Affairs San Diego Healthcare System (VASDHS).  He has held a number of leadership positions at UCSD, including Associate Vice Chancellor for Research Facilities in the Office of Research Affairs, where his portfolio included oversight of the animal welfare program and university-wide shared resources.  Dr. Webster has served as chair of a number of university committees, including the Radiation Safety and Surveillance Committee, the Animal Program Oversight Committee, the Recruitment and Admission Committee for the Biomedical Sciences Graduate Program, the Shared Resources Oversight Committee, and the Research Space Committees at the VASDHS.

Over the past 25 years, Dr. Webster has maintained an active research program, which is broadly focused on the mechanisms of hormonal signal transduction and gene regulation in different developmental and disease contexts.  He actively participates in the Center for Reproductive Science and Medicine, the Diabetes Research Center, and the Center for Transdisciplinary Research in Energetics and Cancer.

Nai-Wen Chi, MD, PhD

Nai-Wen Chi, MD, PhD

The newly appointed vice chair of the Division of Endocrinology and Metabolism, Dr. Nai-Wen Chi, is a researcher and board-certified endocrinologist at the UCSD Medical Center and the VA. Dr. Chi earned his M.D. from National Taiwan University prior to receiving his Ph.D. from Harvard University, where he was mentored by Dr. Richard Kolodner in investigating the molecular machinery that maintains the yeast mitochondrial genome.  Dr. Chi then completed his medical residency and endocrine fellowship at the Massachusetts General Hospital.  During his postdoctoral fellowship at MIT, he was mentored by Dr. Harvey Lodish in identifying novel insulin-signaling molecules that regulate vesicular trafficking.

Dr. Chi joined the UCSD faculty in 2000 and has been the director of the Endocrine Fellowship since 2005.  His clinical interest focuses on dysnatremias while his research program takes biochemical and genetic approaches to investigate the pathophysiology of diabetes and obesity.

Please join me in giving your enthusiastic support to Drs. Nick Webster and Nai-Wen Chi in their new positions of leadership in the Department of Medicine.

How DNA Damage Affects Golgi – The Cell’s Shipping Department

In studying the impact of DNA damage on the Golgi, a research team from the University of California, San Diego School of Medicine and the Ludwig Institute for Cancer Research have discovered a novel pathway activated by DNA damage, with important consequences for the body’s cellular response to chemotherapy. … Read the full story from the UC San Diego News Center


Dr. Seth FieldStudy principal investigator Seth J. Field, MD, PhD, is associate professor of medicine in the Division of Endocrinology and Metabolism.

Visit Dr. Field’s Laboratory Website

Citation for the study report in Cell: Suzette E. Farber-Katz, Holly C. Dippold, Matthew D. Buschman, Marshall C. Peterman, Mengke Xing, Christopher J. Noakes, John Tat, Michelle M. Ng, Juliati Rahajeng, David M. Cowan, Greg J. Fuchs, Huilin Zhou, Seth J. Field, DNA Damage Triggers Golgi Dispersal via DNA-PK and GOLPH3, Cell, Volume 156, Issue 3, 30 January 2014, Pages 413-427, ISSN 0092-8674. Summary | Full text (UCSD only)

Checkup Diabetes: the Latest Research and Treatments from UC San Diego

News Feature from the UC San Diego Health System Newsroom

Checkup Diabetes: the latest research and treatments at UC San Diego

by Scott LaFee

Diabetes is a monumental public health issue, not just because millions of Americans have been diagnosed with the metabolic disease, but also for the many more millions who either remain undiagnosed or have signs suggesting they will likely become diabetic. .. Read the full news feature from the UC San Diego Health System newsroom

High Rankings for Internal Medicine Specialties in 2013-2014 “America’s Best Hospitals” Report

Internal medicine subspecialties received high rankings and played a large part in UC San Diego Health System’s excellent showing in the U.S. News & World Report “America’s Best Hospitals 2013-2014” guide released July 16.

Clinical efforts of Department of Medicine divisions are either partly or completely responsible for 7 of the 10 UC San Diego Health System adult specialties that ranked in the nation’s top 50 this year and 1 of the 4 ranked as high performing:

In addition, Rheumatology is ranked as high performing once again (Division of Rheumatology, Allergy & Immunology).

Last year, three Department of Medicine specialties ranked in the nation’s top 50 and five were rated high performing.

Wolfgang H. Dillmann, MD“We can be very proud of achieving such a significant rise in our specialty rankings in one year,” said Wolfgang H. Dillmann, MD, Helen M. Ranney Distinguished Professor and Chair of the Department of Medicine.

In an announcement to the Department of Medicine faculty, he said, “Thank you for your hard work and your dedication in your patient care activities.

“Your efforts play a major part in distinguishing UC San Diego Health System as one of the finest hospitals in the country, and the top hospital in the San Diego metropolitan area.”

Details of the rankings for UC San Diego Health System are published online here. |  More about the methodology

UC San Diego Health System Ranks #1

UC San Diego Health System is once again ranked among the nation’s best in U.S. News & World Report’s 2013-14 “America’s Best Hospitals” issue. The magazine placed UC San Diego Health System #1 in the San Diego metropolitan area with national rankings in 10 specialties—placing it among the country’s most prestigious institutions. … Read the full story from the UCSD Newsroom


Doctor and patient. Stock photo.

Rankings for UC San Diego Health System Internal Medicine Subspecialties

In the nation’s Top 50:

High Performing:

Details of the rankings for UC San Diego Health System are published online here.

Four Common Antipsychotic Drugs Found to Lack Safety and Effectiveness in Older Adults

In older adults, antipsychotic drugs are commonly prescribed off-label for a number of disorders outside of their Food and Drug Administration (FDA)-approved indications – schizophrenia and bipolar disorder. The largest number of antipsychotic prescriptions in older adults is for behavioral disturbances associated with dementia, some of which carry FDA warnings on prescription information for these drugs.

In a new study – led by researchers at the University of California, San Diego School of Medicine, Stanford University and the University of Iowa, and funded by the National Institute of Mental Health – four of the antipsychotics most commonly prescribed off label for use in patients over 40 were found to lack both safety and effectiveness. … Read the full story from the UCSD Newsroom


Department of Medicine endocrinology and metabolism researchers Robert R. Henry, MD, and Sunder Mudaliar, MD, are coinvestigators in the study of the antipsychotic drugs.Dr. Robert R. Henry

Robert R. Henry, MD, is professor of medicine in the Division of Endocrinology & Metabolism at UC San Diego. At the Veterans Affairs San Diego Healthcare System (VASDHS), he is Chief of the Section of Endocrinology, Metabolism & Diabetes and Director of the Center for Metabolic Research.

Sunder Mudaliar, MD, is health sciences clinical professor in the Division of Endocrinology & Metabolism at UCSD. He is extensively involved in medical teaching and clinical care at the VASDHS. As an investigator in the Center for Metabolic Research, he performs clinical research focused on the prevention and treatment of diabetes.

More information:

Citation for the study report: Jin H, Shih PB,Golshan S, Mudaliar S, Henry R, Glorioso DK, Arndt S, Kraemer HC, Jeste DV. Comparison of Longer-Term Safety and Effectiveness of 4 Atypical Antipsychotics in Patients Over Age 40: A Trial Using Equipoise-Stratified Randomization. E-pub ahead of print, November 27, 2012, The Journal of Clinical Psychiatry.

Vitamin D Deficiency Linked to Type 1 Diabetes

 

A study led by researchers from the University of California, San Diego School of Medicine has found a correlation between vitamin D3 serum levels and subsequent incidence of Type 1 diabetes.  The six-year study of blood levels of nearly 2,000 individuals suggests a preventive role for vitamin D3 in this disease.  The research appears the December issue of Diabetologia, a publication of the European Association for the Study of Diabetes (EASD). … Read the full story from the UCSD Newsroom


Heather Hofflich, DOHeather Hofflich, DO, Health Sciences associate clinical professor in the Division of General Internal Medicine, is a coauthor of the report.

Citation for the report: Gorham ED, Garland CF, Burgi AA, Mohr SB, Zeng K, Hofflich H, Kim JJ, Ricordi C. Lower prediagnostic serum 25-hydroxyvitamin D concentration is associated with higher risk of insulin-requiring diabetes: a nested case–control study. Diabetologia 2012; 55:3224–3227. DOI: 10.1007/s00125-012-2709-8. Epub 2012 Sep 7. PMID:22955995.

BPA’s Real Threat May Be After It Has Metabolized

Chemical found in many plastics linked to multiple health threats

Bisphenol A or BPA is a synthetic chemical widely used in the making of plastic products ranging from bottles and food can linings to toys and water supply lines. When these plastics degrade, BPA is released into the environment and routinely ingested… Read the full story from the UCSD Newsroom


Department of Medicine researcher Michael E. Baker, PhD, teamed with UCSD Department of Bioengineering graduate student Charlie Chandsawangbhuwana in the study. Dr. Baker is a research scientist in the Division of Nephrology/Hypertension.

Chronic Stress Spawns Protein Aggregates Linked to Alzheimer’s

Repeated stress triggers the production and accumulation of insoluble tau protein aggregates inside the brain cells of mice, say researchers at the University of California, San Diego School of Medicine in a new study published in the March 26 Online Early Edition of the Proceedings of the National Academy of Sciences. … Read the full story from the UCSD Newsroom


Dr. Wylie Vale Dr. Wylie Vale was one of two Salk Institute for Biological Studies researchers who contributed to this research. Dr. Vale, who held an adjunct professorship in the Division of Endocrinology and Metabolism, collaborated on numerous research projects at UC San Diego. He passed away on January 6, 2012.  |  Read memorial

Read abstract of study report

Citation for the study report: Rissman RA, Staup MA, Lee AR, Justice NJ, Rice KC, Vale W, Sawchenko PE. Corticotropin-releasing factor receptor-dependent effects of repeated stress on tau phosphorylation, solubility, and aggregation. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6277-82. doi: 10.1073/pnas.1203140109. Epub 2012 Mar 26.