Yeast, human cells and bioinformatics help develop one-two punch approach to personalized cancer therapy —
In an effort to expand the number of cancer gene mutations that can be specifically targeted with personalized therapies, researchers at University of California San Diego School of Medicine and Moores Cancer Center looked for combinations of mutated genes and drugs that together kill cancer cells. Such combinations are expected to kill cancer cells, which have mutations, but not healthy cells, which do not. The study, published July 21 in Molecular Cell, uncovered 172 new combinations that could form the basis for future cancer therapies.
Researchers find that the genetic causes of autism consist of a wide variety of genetic changes —
The types of gene mutations that contribute to autism are more diverse than previously thought, report researchers at University of California, San Diego School of Medicine in the March 24 online issue of The American Journal of Human Genetics. The findings, they say, represent a significant advance in efforts to unravel the genetic basis of autism spectrum disorder (ASD). …Read the Full Story from the UC San Diego Newsroom
He conducts neurodevelopmental research with particular interest in rare diseases, epilepsy and autism.
Dr. Vaux did his internship and received his pediatrics residency training at the Naval Medical Center, San Diego. In his fellowship work in dysmorphology and medical genetics, Dr. Kenneth Lyons Jones was his mentor.
Researchers identify key proteins that help establish cell function
Researchers at the University of California, San Diego School of Medicine have developed a new way to parse and understand how special proteins called “master regulators” read the genome, and consequently turn genes on and off. … Read the full story from the UC San Diego News Center
An international team, headed by researchers at the University of California, San Diego School of Medicine, has identified a key enzyme in the reprogramming process that promotes malignant stem cell cloning and the growth of chronic myeloid leukemia (CML), a cancer of the blood and marrow that experts say is increasing in prevalence. … Read the full story from the UCSD Newsroom
Citation for the report in PNAS: Jiang Q, Crews LA, Barrett CL, Chun H-J, Court AC, Isquith JM, Zipeto MA, Goff DJ, Minden M, Sadarangani A, Rusert JM, Dao K-HT, Morris SR, Goldstein LSB, Marra MA, Kelly A. Frazer KA, Jamieson C.H.M. ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia. PNAS 2012; published ahead of print December 28, 2012, doi:10.1073/pnas.1213021110