Howard J. Jacob to Deliver Daniel T. O’Connor Memorial Lecture February 23

Dr. Howard J. Jacob will present the Daniel T. O’Connor 2nd Annual Memorial Lecture on Thursday, February 23, 2017, at UC San Diego School of Medicine. His topic is “From Hypertension to Genomic Medicine.”

Dr. Jacob’s lecture will take place in the Leichtag Auditorium (Room 107), with a reception immediately following on the patio.

Dr. Jacob is Executive Vice President for Medical Genomics, Chief Medical Genomics Officer, and Faculty Investigator at HudsonAlpha Institute for Biotechnology. His UC San Diego hosts are Bruce A. Hamilton, PhD, and Nicholas J. Schork, PhD.

Dr. Hamilton is Professor, Cellular and Molecular Medicine, Department of Medicine; Director, Genetics Training Program; and Associate Director, Institute for Genomic Medicine. Dr. Schork is UC San Diego Adjunct Professor, Psychiatry, Family and Preventive Medicine and Director of Human Biology, J. Craig Venter Institute.

The lecture is presented in conjunction with the UC San Diego CTRI Seminar Series and the Genetics, Bioinformatics and Systems Biology Colloquium Series.

Personalized Medicine Leads to Better Outcomes for Patients with Cancer

In a meta-analysis of hundreds of clinical trials involving thousands of patients, researchers at University of California San Diego School of Medicine report that therapeutic approaches using precision medicine, which emphasizes the use of individual genetics to refine cancer treatment, showed improved response and longer periods of disease remission, even in phase I trials.

The findings are published in the June 6, 2016 issue of JAMA Oncology. … Read the Full Story from the UC San Diego Newsroom


Dr. Razelle Kurzrock

Dr. Razelle Kurzrock

The senior author of the report in JAMA Oncology is Razelle Kurzrock, MD, Director of the Center for Personalized Cancer Therapy and Clinical Trials Office at Moores Cancer Center.

Dr. Kurzrock is Chief of the Division of Hematology-Oncology in the Department of Medicine.

Fatty Liver Disease and Scarring Have Strong Genetic Component

Researchers at the University of California, San Diego School of Medicine say that hepatic fibrosis, which involves scarring of the liver that can result in dysfunction and, in severe cases, cirrhosis and cancer, may be as much a consequence of genetics as environmental factors.

The findings are published online in the journal Gastroenterology. … Read the Full Story from the UC San Diego Newsroom

Clinical Trial Launched to Assess Safety and Efficacy of Autism Drug Treatment

UC San Diego researchers open first study of suramin in children with autism —

Researchers at the University of California, San Diego School of Medicine have launched a clinical trial to investigate the safety and efficacy of an unprecedented drug therapy for autism.

The phase 1 clinical trial, which is recruiting 20 qualifying participants, will evaluate suramin – a century-old drug still used for African sleeping sickness – as a novel treatment for children with a diagnosis of Autism Spectrum Disorder (ASD). Previous published research by Robert K. Naviaux, MD, PhD, professor of medicine, pediatrics and pathology at UC San Diego School of Medicine, and colleagues reported that a single injection of suramin reversed symptoms of ASD in mouse models. …Read the full story from the UC San Diego Newsroom


Senior author Robert K. Naviaux, MD, PhD, is professor of medicine in the Division of Medical Genetics. He co-directs the Mitochondrial and Metabolic Disease Center at UC San Diego.

Visit the Naviaux Laboratory website

Dr. Trey Ideker Named AAAS Fellow

Trey Ideker, PhD

Trey Ideker, PhD

Trey Ideker, PhD, professor of medicine in the Division of Medical Genetics and professor of bioengineering, is one of three UC San Diego faculty members to be named Fellow of the American Association for the Advancement of Science (AAAS) this year. …Read the full story from the UC San Diego Newsroom.

 

In Memoriam: Daniel T. O’Connor, MD

Dr. Daniel T. O'Connor

Daniel T. O’Connor, MD

Announcement from Wolfgang H. Dillmann, MD, Helen M. Ranney Distinguished Professor and Chair of the Department of Medicine

Wolfgang H. Dillmann, MD

Wolfgang H. Dillmann, MD

It is with great sadness that we announce the passing of Daniel T. O’Connor, MD, a longstanding and beloved member of the faculty of the UCSD School of Medicine. He passed away peacefully at his home on August 6, 2014.

Dr. O’Connor graduated from the UC Davis School of Medicine in 1974 and completed both residency and fellowship at UCSD. He joined the faculty in the Division of Nephrology-Hypertension in 1979, after a productive fellowship with Richard Stone, MD, that focused on the sympathetic nervous system in hypertension.  Dr. O’Connor developed an early interest in the proteins that package neurotransmitters, particularly Chromogranin A.  His work on this molecule led to numerous awards including election to the American Society for Clinical Investigation (ASCI), the Harry Goldblatt Award for cardiovascular Research, a UC Davis distinguished alumnus award, a UCSD Faculty Distinguished Lecturer Award, an Established Investigator of the American Heart Association award and presidency of the American Society for Pharmacology and Experimental Therapeutics (ASPET)/ Federation of Societies for Experimental Biology (FASEB).  His work with Chromogranin A led directly to a blood test for endocrine tumors that is still in use, particularly to diagnose pheochromocytoma.  He discovered that catestatin, a proteolytic product of Chromogranin A, is an important regulator of blood pressure.  Catestatin and congeners are currently in development for clinical use.  Dr. O’Connor’s laboratory was funded by large research grants from the National Institutes of Health, including SCOR in Hypertension and Program Project Grants on the role of adrenergic activity in the regulation of blood pressure.  He published well over 350 original articles in first-rate peer-reviewed journals. Dr. O’Connor’s research spanned basic biochemistry through clinical trials, giving his many trainees invaluable skills across the full spectrum of medical investigation. The fellows and junior faculty that Dr. O’Connor trained have succeeded in academic medicine, pharmacology, biotechnology, and nephrology.  His approach to research was notable for openness, sharing and collaboration with other labs, and this infectious attitude is carried on by his trainees.

Not only was Dr. O’Connor a highly productive researcher at UCSD and internationally, but also a highly involved faculty citizen at UCSD.  He was an excellent teacher involved in both basic science teaching of MDs and PhDs, and a popular and learned educator in the clinical arena.  He was widely recognized as the consummate teacher and always had time to provide needed information to fellows and junior faculty members.

UCSD has grown justifiably proud of Dr. O’Connor’s achievements in clinical, translational and basic research on a national and international scale, particularly in the areas of adrenergic contributions to blood pressure regulation and the complex role of the genetics of hypertension.   All who had the privilege of working with Dan O’Connor will greatly miss his infectious attitude that academic medicine and research are more fun than work.

 

 

Tumor Suppressor Mutations Alone Don’t Explain Deadly Cancer

Biomarker for head and neck cancers identified

Although mutations in a gene dubbed “the guardian of the genome” are widely recognized as being associated with more aggressive forms of cancer, researchers at the University of California, San Diego School of Medicine have found evidence suggesting that the deleterious health effects of the mutated gene may in large part be due to other genetic abnormalities, at least in squamous cell head and neck cancers. … Read the full story from the UCSD Newsroom


Trey Ideker, PhD

Trey Ideker, PhD, professor and chief in the Division of Medical Genetics and professor of bioengineering, is one of the study’s co-senior authors.

Other Department of Medicine faculty authors include Hannah Carter, PhD, assistant professor; and Scott M. Lippman, MD, professor of medicine and director of the UC San Diego Moores Cancer Center.

Hannah Carter, PhD Dr. Scott M. Lippman

Hannah Carter Receives NIH Early Independence Award

CTRI Helps Launch Career of Bioengineer Hannah Carter

November 22, 2013 – With support from UC San Diego’s Clinical and Translational Research Institute (CTRI), bioengineer Hannah Carter, PhD, received the highly prestigious NIH Early Independence Award and recently began began her transition to a junior faculty position at UC San Diego.

Presently she is acquiring a research team and computational resources to delve into her project: Network approaches to identify cancer drivers from high-dimensional tumor data. … Read the full story from CTRI News & Events


Hannah Carter, PhDHannah Carter, PhD, is assistant professor of medicine in the Division of Medical Genetics. Her project is Network Approaches to Identify Cancer Drivers from High-Dimensional Tumor Data.

She is now recruiting postdoctoral fellows for her project, which is funded for five years.

Carter Laboratory website

 

The Role of “Master Regulators” in Gene Mutations and Disease

Researchers identify key proteins that help establish cell function

Researchers at the University of California, San Diego School of Medicine have developed a new way to parse and understand how special proteins called “master regulators” read the genome, and consequently turn genes on and off. … Read the full story from the UC San Diego News Center


Christopher K. Glass, MD, PhDThe principal investigator of the reported study is Christopher K. Glass, MD, PhD, professor of medicine in the Division of Endocrinology & Metabolism and professor of cellular and molecular medicine at UC San Diego.

He is on the faculty of the UC San Diego Institute for Genomic Medicine.

Visit the Glass Laboratory website.

Related UC San Diego news stories:

$5.6 Million Grant Renewal Expands Research in Kidney Failure

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDKD) – part of the National Institutes of Health – has renewed a grant shared by the University of California, San Diego and the University of Alabama at Birmingham Schools of Medicine. The five-year, $5.64 million renewal will extend and expand research into acute kidney failure, or acute kidney injury, which kills 70 to 80 percent of patients in intensive care units who develop the disease.Read the full story from the UCSD Newsroom


Dr. Ravindra MehtaRavindra L. Mehta, MD, FACP, UC San Diego professor of clinical medicine and vice chair for clinical research in the Department of Medicine, is associate director of the UC San Diego – University of Alabama at Birmingham O’Brien Center for Acute Kidney Injury Research.

He directs the O’Brien Center’s clinical studies core with co-director Daniel O’Connor, MD. O’Connor is professor of medicine and pharmacology and co-director, UCSD Center for Human Genetics and Genomics.

UC San Diego nephrology faculty members Roland Blantz, MD, and Volker Vallon, MD, are co-directors of the pre-clinical studies core of the O’Brien Center. Blantz is distinguished professor of medicine emeritus and former chief of the Division of Nephrology-Hypertension; Vallon is professor of medicine and pharmacology.

UC San Diego nephrologist Satish RamachandraRao, PhD, assistant professor of medicine, is a co-director of the Bioanalytical Resource Core.

Ravindra L. Mehta is Director of Dialysis Programs and Clinical Nephrology for UC San Diego Health System. In the UC San Diego School of Medicine, Mehta directs the Clinical Research Enhancement through Supplemental Training (CREST) and Master’s Degree in Clinical Research programs.

In 2011, Mehta received the International Society of Nephrology (ISN) Shire Bywaters Award for his lifetime achievements in acute kidney injury.

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