Enzyme Restores Function with Diabetic Kidney Disease

Mouse findings reverse prevailing theory; point to potential treatment options

Researchers at the University of California, San Diego School of Medicine say that, while a prevailing theory suggests elevated cellular levels of glucose ultimately result in diabetic kidney disease, the truth may, in fact, be quite the opposite. The findings could fundamentally change understanding of how diabetes-related diseases develop – and how they might be better treated. … Read the full story from the UC San Diego News Center


Kumar Sharma, MD, FAHA Kumar Sharma, MD, FAHA, senior author of the study report, is professor of medicine and director of the Center for Renal Translational Medicine in the Division of Nephrology-Hypertension.

Dr. Laura DuganFirst author Laura L. Dugan, MD, at right, is professor of neurosciences and professor and chief of the Division of Geriatrics in the Department of Medicine. She holds the Larry L. Hillblom Chair in Geriatric Medicine.

Second author Young-Hyun You is an associate project scientist in the Division of Nephrology-Hypertension,

Other DOM faculty coauthors are Sameh S. Ali, assistant professor of medicine in the Division of Geriatrics, and Robert K. Naviaux, MD, PhD, professor of medicine in the Division of Medical Genetics.

Citation for the study report:

Laura L. Dugan, Young-Hyun You, Sameh S. Ali, Maggie Diamond-Stanic, Satoshi Miyamoto, Anne-Emilie DeCleves, Aleksander Andreyev, Tammy Quach, San Ly, Grigory Shekhtman, William Nguyen, Andre Chepetan, Thuy P. Le, Lin Wang, Ming Xu, Kacie P. Paik, Agnes Fogo, Benoit Viollet, Anne Murphy, Frank Brosius, Robert K. Naviaux and Kumar Sharma. AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function. J Clin Invest. 2013;123(11):4888–4899. doi:10.1172/JCI66218.  |  Full text (UCSD only)

Related UC San Diego news stories:

Checkup Diabetes: the Latest Research and Treatments from UC San Diego

News Feature from the UC San Diego Health System Newsroom

Checkup Diabetes: the latest research and treatments at UC San Diego

by Scott LaFee

Diabetes is a monumental public health issue, not just because millions of Americans have been diagnosed with the metabolic disease, but also for the many more millions who either remain undiagnosed or have signs suggesting they will likely become diabetic. .. Read the full news feature from the UC San Diego Health System newsroom

Four Common Antipsychotic Drugs Found to Lack Safety and Effectiveness in Older Adults

In older adults, antipsychotic drugs are commonly prescribed off-label for a number of disorders outside of their Food and Drug Administration (FDA)-approved indications – schizophrenia and bipolar disorder. The largest number of antipsychotic prescriptions in older adults is for behavioral disturbances associated with dementia, some of which carry FDA warnings on prescription information for these drugs.

In a new study – led by researchers at the University of California, San Diego School of Medicine, Stanford University and the University of Iowa, and funded by the National Institute of Mental Health – four of the antipsychotics most commonly prescribed off label for use in patients over 40 were found to lack both safety and effectiveness. … Read the full story from the UCSD Newsroom


Department of Medicine endocrinology and metabolism researchers Robert R. Henry, MD, and Sunder Mudaliar, MD, are coinvestigators in the study of the antipsychotic drugs.Dr. Robert R. Henry

Robert R. Henry, MD, is professor of medicine in the Division of Endocrinology & Metabolism at UC San Diego. At the Veterans Affairs San Diego Healthcare System (VASDHS), he is Chief of the Section of Endocrinology, Metabolism & Diabetes and Director of the Center for Metabolic Research.

Sunder Mudaliar, MD, is health sciences clinical professor in the Division of Endocrinology & Metabolism at UCSD. He is extensively involved in medical teaching and clinical care at the VASDHS. As an investigator in the Center for Metabolic Research, he performs clinical research focused on the prevention and treatment of diabetes.

More information:

Citation for the study report: Jin H, Shih PB,Golshan S, Mudaliar S, Henry R, Glorioso DK, Arndt S, Kraemer HC, Jeste DV. Comparison of Longer-Term Safety and Effectiveness of 4 Atypical Antipsychotics in Patients Over Age 40: A Trial Using Equipoise-Stratified Randomization. E-pub ahead of print, November 27, 2012, The Journal of Clinical Psychiatry.

Moving Ahead With the Leadership of Interim Chair Wolfgang H. Dillmann, M.D.

Wolfgang Dillmann, MDWolfgang H. Dillmann, MD, a respected division chief and internationally recognized physician-scientist, assumes leadership of the Department of Medicine this week as Dr. Ken Kaushansky departs for his new position as Senior Vice President for Health Sciences and Dean of the School of Medicine at Stony Brook University in New York.

“Wolf has made major contributions to the Department of Medicine for decades, in the realms of science, teaching and clinical care,” said Dr. Kaushansky.

“Now, by taking on the challenging role as interim Chair, he will make even greater contributions to the students, residents, fellows and faculty who call the department home.”

Dr. Dillmann, Professor of Medicine and Chief of the Division of Endocrinology and Metabolism, has served the Department for many years in positions on the Finance Committee and the Space Committee.

Dr. Joe Witztum, Professor of Medicine and Dr Dillmann’s longtime colleague in the division, described him as a dedicated and thoughtful leader, a superb clinician, and a true physician-scientist. “I’m not surprised that he was asked to be Interim Chair,” he said.

Dr. Tom Savides Named Executive Vice Chair

New positions in the Department of Medicine leadership team will support Dr. Dillmann in his interim role. Dr. Tom Savides, Professor of Clinical Medicine and Interim Chief of the Division of Gastroenterology, will serve as Executive Vice Chair.

Dr. Savides also holds the positions of Clinical Service Chief for Gastroenterology, Director of the Gastroenterology Fellowship Program, and Director of Advanced GI Endoscopy.

Dr. Richard Gallo, Professor of Medicine and Pediatrics and Chief of the Division of Dermatology, will serve as Vice Chair for Laboratory Research and co-chair, with Dr. Robert Schooley, of the department’s Space Committee.

Dr. Schooley, Professor of Medicine and Chief of the Division of Infectious Diseases, will continue as Vice Chair for Academic Affairs.

As before, Drs. Elaine Muchmore, Dan Bouland, Francis Gabbai and Ravi Mehta will serve as the vice chairs for Education, Clinical Operations, VASDHS Affairs, and Clinical Research, respectively. Maureen O’Connor is Vice Chair for Administration.

About Dr. Dillmann

“Wolf is an old-fashioned physician-scientist,” said Dr. Witztum, who joined the faculty within months of Dr. Dillmann in 1979. “In the old days, we used to talk about the ‘triple threat’ – physician, scientist, and teacher. It’s hard to do all three, particularly these days, and Wolf still really does it well.”

In his clinical activities, Dr. Dillmann specializes in endocrine diseases, especially thyroid disease. His research activities are directed at endocrine and metabolic influence on cardiovascular function.

Over the years, he has maintained a deep involvement in clinical work despite the expansion in his other roles. “He’s a superb endocrinologist and internal medicine doctor,” Dr. Witztum said.

“He’s dedicated to providing good clinical services,” he said. “He works very hard to develop clinical programs, particularly for the care of diabetic and metabolic syndrome patients.”

In recent months, Dr. Dillmann has led the division through a successful recertification of the Endocrine Fellowship Training Program. He is an active teacher in the Department of Medicine’s core courses in the School of Medicine and he serves as mentor for postdoctoral fellows and medical students.

Dr. Dillmann’s research focused initially on thyroid disease and its effects on heart function. His work has expanded in recent years to examine the biochemical and cellular properties of heart cells and the ways in which they are affected by thyroid hormone and glucose metabolism.

“He has become an international expert on cardiac metabolism in general,” Dr. Witztum said. “His studies are of interest not only to endocrinologists but also to cardiologists who are interested in the basic mechanisms by which the heart works.”

Dr. Dillmann is a member of the Diabetes and Endocrinology Research Center (DERC), the Institute of Engineering in Medicine, and the Cardiac Mechanics Research Group at UCSD.

He serves as reviewer for a number of major scientific journals including the Journal of Clinical Investigation, Endocrinology, American Journal of Physiology, the Journal of Biological Chemistry, Circulation, and Circulation Research.

View Dr. Dillmann’s list of publications (PubMed)

Dr. Dillmann was born in Germany. After he received his MD degree from the University of Munich in 1970, he came to the United States to do his medical internship at City Hospital Center, Elmhurst, Mt. Sinai Hospital in New York City.

He completed his residency training in 1972 and his endocrinology and metabolism fellowship training in 1975 at Albert Einstein College of Medicine in Bronx, New York. After a year as Assistant Professor of Medicine there, he moved to the University of Minnesota, where he held the position of Assistant Professor of Medicine from 1976 through 1978.

In 1979, Dr. Dillmann joined the UC San Diego School of Medicine faculty as Assistant Professor in the Division of Endocrinology and Metabolism. He was promoted to Associate Professor in 1981 and to Professor in 1987. In 2005, he became chief of the division.

He is a member of the American Society for Clinical Investigation and the Association of American Physicians.

Overnight Fasting May Reduce Breast Cancer Risk in Women

A decrease in the amount of time spent eating and an increase in overnight fasting reduces glucose levels and may reduce the risk of breast cancer among women, report University of California, San Diego School of Medicine researchers in the journal Cancer Epidemiology, Biomarkers & Prevention. … Read the full story from the UC San Diego Newsroom