Researchers Find Key Player in Diabetic Kidney Disease Through Power of Metabolomics

Tapping the potential of metabolomics, an emerging field focused on the chemical processes of metabolism, researchers at University of California, San Diego School of Medicine have identified a new and pivotal player in diabetic kidney disease.

The study, published online July 22 in the Journal of the American Society of Nephrology, also clarifies a central mechanism of action in diabetic kidney disease that is generating considerable excitement among researchers and the biopharmaceutical community. The mechanism, involving the NADPH (nicotinamide adenine dinucleotide phosphate) oxidase (NOX) proteins, NOX1 and NOX4, is now the subject of a phase II clinical trial for the treatment of diabetic kidney disease. … Read the Full Story from the UC San Diego News Center


Kumar Sharma, MD, FAHASenior author of the study report is Kumar Sharma, MD, FAHA, professor of medicine in the Division of Nephrology and director of the Center for Renal Translational Medicine at UC San Diego School of Medicine.

Read the study report in the Journal of the American Society of Nephrology  (UC San Diego Only)

Researchers Boost Body’s Inflammation-Reduction Mechanism to Combat Obesity-Fueled Disease

Researchers at University of California, San Diego School of Medicine and University College Dublin (UCD) have found that augmenting a naturally occurring molecule in the body can help protect against obesity-related diseases by reducing inflammation in the fat tissues. The study, published June 4 in the journal Cell Metabolism, focused on liver and kidney diseases, but the researchers believe it could lead to a new therapeutic approach for a variety of obesity-fueled conditions.

“This is a new way of reducing inflammation and protecting organs, using a compound that’s already produced by the body,” said co-senior author Kumar Sharma, MD, a professor of medicine and director of the Center for Renal Translational Medicine at UC San Diego School of Medicine. “Essentially, we’re boosting the body’s natural response for reducing inflammation and showing the benefit in obesity-driven diseases.” … Read the full story from the UC San Diego Newsroom

Joachim H. Ix Named Chief of Nephrology-Hypertension

January 2, 2014

Announcement from Wolfgang H. Dillmann, MD
Helen M. Ranney Distinguished Professor and Chair

Dr. Joachim Ix

Dr. Joachim Ix

I am very pleased to announce that Dr. Joachim H. Ix, who has served as interim chief of the Division of Nephrology-Hypertension since Dr. Roland Blantz retired in 2012, has been selected as the new chief of the division. His new appointment was effective December 17, 2013.

Dr. Ix has managed the division with effectiveness and wisdom during his year as interim chief, balancing and advancing its activities during a time that has brought particularly difficult fiscal and managerial challenges to all of us. I am confident that the Division of Nephrology-Hypertension will continue to grow in clinical and academic stature with his leadership.

Joachim H. Ix, MD, MAS, is professor of medicine and professor of family and preventive medicine at UC San Diego. He is active as a clinical specialist in the diagnosis and management of kidney disease patients at both UC San Diego Health System and the Veterans Affairs San Diego Healthcare System (VASDHS). He directed the VASDHS chronic kidney disease clinic in 2008-2009 and subsequently the VASDHS Dialysis Unit from 2009-2013.

A creative and productive clinical trialist and epidemiologist, Dr. Ix investigates the contributions of altered calcium and phosphorus homeostasis to cardiovascular disease in patients with kidney disease. He has more than 140 published articles in peer-reviewed journals. His active National Institutes of Health funded studies include a 5-year U01 cooperative project, begun in September of this year, in which he will conduct a phase 2 clinical trial to test the efficacy of nicotinamide (vitamin B3) on phosphorus homeostasis and other components of mineral metabolism in CKD patients. He is also PI of a recently funded R01 award evaluating the contributions of kidney tubule dysfunction and injury to progression of kidney disease and cardiovascular disease, and was recently funded as PI of an American Heart Association Established Investigator Award.

He was elected a fellow of the American Society of Nephrology in 2010 and is associate editor of the American Journal of Kidney Diseases, a standing member of the NIH Study Section on Kidney Nutrition Obesity and Diabetes (KNOD) and a member of the SPRINT Trial Chronic Kidney Disease Advisory Group.

Dr. Ix is a dedicated teacher and mentor and an active contributor to his division’s instructional efforts at all levels, including the nephrology fellowship program and the School of Medicine curriculum. In 2010, he received the Excellence in Teaching Award in recognition for outstanding teaching contributions in the third-year Medicine Core Clerkship course.

Dr. Ix earned his Bachelor of Science degree at UC San Diego and his medical degree at the University of Chicago Pritzker School of Medicine. He received his specialty training, nephrology fellowship training, and MAS in biostatistics and epidemiology at UC San Francisco. He joined the UC San Diego faculty in 2007.