Researchers Boost Body’s Inflammation-Reduction Mechanism to Combat Obesity-Fueled Disease

Researchers at University of California, San Diego School of Medicine and University College Dublin (UCD) have found that augmenting a naturally occurring molecule in the body can help protect against obesity-related diseases by reducing inflammation in the fat tissues. The study, published June 4 in the journal Cell Metabolism, focused on liver and kidney diseases, but the researchers believe it could lead to a new therapeutic approach for a variety of obesity-fueled conditions.

“This is a new way of reducing inflammation and protecting organs, using a compound that’s already produced by the body,” said co-senior author Kumar Sharma, MD, a professor of medicine and director of the Center for Renal Translational Medicine at UC San Diego School of Medicine. “Essentially, we’re boosting the body’s natural response for reducing inflammation and showing the benefit in obesity-driven diseases.” … Read the full story from the UC San Diego Newsroom

$5.6 Million Grant Renewal Expands Research in Kidney Failure

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDKD) – part of the National Institutes of Health – has renewed a grant shared by the University of California, San Diego and the University of Alabama at Birmingham Schools of Medicine. The five-year, $5.64 million renewal will extend and expand research into acute kidney failure, or acute kidney injury, which kills 70 to 80 percent of patients in intensive care units who develop the disease.Read the full story from the UCSD Newsroom


Dr. Ravindra MehtaRavindra L. Mehta, MD, FACP, UC San Diego professor of clinical medicine and vice chair for clinical research in the Department of Medicine, is associate director of the UC San Diego – University of Alabama at Birmingham O’Brien Center for Acute Kidney Injury Research.

He directs the O’Brien Center’s clinical studies core with co-director Daniel O’Connor, MD. O’Connor is professor of medicine and pharmacology and co-director, UCSD Center for Human Genetics and Genomics.

UC San Diego nephrology faculty members Roland Blantz, MD, and Volker Vallon, MD, are co-directors of the pre-clinical studies core of the O’Brien Center. Blantz is distinguished professor of medicine emeritus and former chief of the Division of Nephrology-Hypertension; Vallon is professor of medicine and pharmacology.

UC San Diego nephrologist Satish RamachandraRao, PhD, assistant professor of medicine, is a co-director of the Bioanalytical Resource Core.

Ravindra L. Mehta is Director of Dialysis Programs and Clinical Nephrology for UC San Diego Health System. In the UC San Diego School of Medicine, Mehta directs the Clinical Research Enhancement through Supplemental Training (CREST) and Master’s Degree in Clinical Research programs.

In 2011, Mehta received the International Society of Nephrology (ISN) Shire Bywaters Award for his lifetime achievements in acute kidney injury.

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