Researchers Find Link Between Inflammation, Tissue Regeneration and Wound Repair Response

Discovery has implications for potential new treatments of some cancers and inflammatory bowel disease —

Almost all injuries, even minor skin scratches, trigger an inflammatory response, which provides protection against invading microbes but also turns on regenerative signals needed for healing and injury repair – a process that is generally understood but remains mysterious in its particulars.

Writing in the February 25 online issue of Nature, an international team of scientists, headed by researchers at the University of California, San Diego School of Medicine, report finding new links between inflammation and regeneration: signaling pathways that are activated by a receptor protein called gp130.. … Read the full story from the UC San Diego Newsroom

Dr. William SandbornStudy coinvestigators included Division of Gastroenterology division chief William Sandborn, MD, and Inflammatory Disease Center researchers Brigid S. Boland and John T. Chang.

Other Department of Medicine coauthors included Petrus R. de Jong; and Samuel B. Ho, professor of medicine in the Division of Gastroenterology and Section Chief, Gastroenterology, at the VA San Diego Healthcare System.

Full text of the article (UC San Diego only)

Promising New Target for Stifling the Growth and Spread of Cancer

UCSD researchers find inhibiting single protein blocks the inflammation that fuels tumors

Cancer and chronic inflammation are partners in peril, with the latter increasing the likelihood that malignant tumors will develop, grow and spread. Researchers at the University of California, San Diego School of Medicine say they’ve identified a tumor inflammation trigger that is common to most, if not all, cancers … Read the full story from the UCSD Newsroom

Dr. Judith A. Varner

The study’s senior investigator is Judith A. Varner, PhD, Professor of Medicine in the Division of Hematology-Oncology and researcher in the Tumor Growth, Invasion and Metastasis Program at UCSD Moores Cancer Center. Collaborators include Department of Medicine faculty members Seth J. Field, MD, PhD, and Mark H. Ginsberg, MD.  |  Read the published study in the June 14, 2011, issue of Cancer Cell (free full text).