Remote Italian Village Could Harbor Secrets of Healthy Aging

Researchers will examine 300 Italian residents, all over 100 years old —

The average life expectancy in the United States is approximately 78 years old. Americans live longer, with better diets and improved health care, than ever before, but only 0.02 percent will hit the century mark.

To understand how people can live longer throughout the world, researchers at University of California, San Diego School of Medicine have teamed up with colleagues at University of Rome La Sapienza to study a group of 300 citizens, all over 100 years old, living in a remote Italian village nestled between the ocean and mountains on the country’s coast.

“We are the first group of researchers to be given permission to study this population in Acciaroli, Italy,” said Alan Maisel, MD … Read the Full Story from the UC San Diego Newsroom

Checkup Diabetes: the Latest Research and Treatments from UC San Diego

News Feature from the UC San Diego Health System Newsroom

Checkup Diabetes: the latest research and treatments at UC San Diego

by Scott LaFee

Diabetes is a monumental public health issue, not just because millions of Americans have been diagnosed with the metabolic disease, but also for the many more millions who either remain undiagnosed or have signs suggesting they will likely become diabetic. .. Read the full news feature from the UC San Diego Health System newsroom

Biomarking Time

Methylome modifications offer new measure of our “biological” age

Women live longer than men. Individuals can appear or feel years younger – or older – than their chronological age. Diseases can affect our aging process. When it comes to biology, our clocks clearly tick differently.

In a new study, researchers at the University of California, San Diego School of Medicine, with colleagues elsewhere, describe markers and a model that quantify how aging occurs at the level of genes and molecules, providing not just a more precise way to determine how old someone is, but also perhaps anticipate or treat ailments and diseases that come with the passage of time. … Read the full story from the UCSD Newsroom


Trey Ideker, PhDTrey Ideker, PhD, is co-senior author of the study report. He is professor of medicine and chief of the Division of Medical Genetics, professor of bioengineering and faculty investigator in the UCSD Institute for Genomic Medicine.The overall goal of Ideker’s work is to map and model molecular networks of cellular processes in health and disease, particularly in cancer and the response to genotoxic stress.

Coauthors of the study report include Rob DeConde, a graduate student in Ideker’s laboratory.

Read the abstract of the study report in PubMed

Citation: Hannum G, Guinney J, Zhao L, Zhang L, Hughes G, Sadda S, Klotzle B, Bibikova M, Fan J-B, Gao Y, Deconde R, Chen M, Rajapakse I, Friend S, Ideker T, Zhang K: Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates. Molecular cell doi:10.1016/j.molcel.2012.10.016. PMID: 23177740

Matters of the Heart: A Q&A with Ehtisham Mahmud

News Feature from the UC San Diego Health System Newsroom

Matters of the Heart: A Q&A with Ehtisham Mahmud
A profile of Dr. Ehtisham Mahmud
Professor and Chief of Cardiovascular Medicine
Co-director of UC San Diego Sulpizio Cardiovascular Center
Director, Interventional Cardiology and Cardiac Catheterization Laboratory

by Scott LaFee

Every 34 seconds, on average, an American has a heart attack. Every minute, someone in the United States dies from a heart disease-related event. Both men and women are afflicted equally, if differently. More than one-quarter of the annual deaths in this country are due to cardiovascular disease in its myriad manifestations. It claims more lives each year than cancer, chronic lower respiratory diseases and accidents combined.”… Read the full profile from the UC San Diego Health System newsroom