New Way of Fighting High Cholesterol Upends Assumptions

Atherosclerosis – the hardening of arteries that is a primary cause of cardiovascular disease and death – has long been presumed to be the fateful consequence of complicated interactions between overabundant cholesterol and resulting inflammation in the heart and blood vessels. … Read the full story from the UCSD Newsroom


Christopher K. GlassSenior author of the study report is Christopher K. Glass, MD, PhD, pictured at left, professor in the Departments of Medicine and Cellular and Molecular Medicine.

The other Department of Medicine coauthors on the study report are Andrew C. Li, MD, PhD, assistant professor of medicine in the Division of Endocrinology and Metabolism; Sotirios Tsimikas, MD, FACC, professor of clinical medicine in the Division of Cardiovascular Medicine; and Oswald Quehenberger, PhD, professor of medicine in the Division of Endocrinology and Metabolism.

Read the report of the study in Cell (full text UCSD only)

Citation of study report: Spann NJ, Garmire LX, McDonald JG, Myers DS, Milne SB, Shibata N, Reichart D, Fox JN, Shaked I, Heudobler D, Raetz CRH, Wang EW, Kelly SL, Sullards MC, Murphy RC, Merrill AH Jr, Brown HA, Dennis EA, Li AC, Ley K, Tsimikas S, Fahy E, Subramaniam S, Quehenberger O, Russell DW, Glass CK. Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell 151(1):138-152, 2012. http://dx.doi.org/10.1016/j.cell.2012.06.054

Insulin Resistance, Inflammation and a Muscle-Saving Protein

In the online May 2 issue of the journal Cell Metabolism, researchers at the University of California, San Diego School of Medicine publish three distinct articles exploring:

  • the complex interactions of lipids and inflammation in insulin resistance
  • the roles of omega 3 fatty acids and a particular gene in fighting inflammation
  • how elevated levels of a particular protein might delay the muscle-destroying effects of amyotrophic lateral sclerosis.

Type 2 diabetes has reached epidemic proportions around the world … Read the full story from the UCSD Newsroom


Dr. Jerrold Olefsky
Dr. Jerrold Olefsky coauthored two of the three articles published:

  • Perspective article: Inflammation and Lipid Signaling in the Etiology of Insulin Resistance – Free full text
  • Omega 3 Fatty Acids and GPR120 – Article summary

Dr. Olefsky is Associate Dean for Scientific Affairs, UC San Diego Health Sciences; and Distinguished Professor of Medicine in the Division of Endocrinology and Metabolism.

Testing Antioxidant Drugs is Transparent

A study using genetically modified zebrafish to visualize early events involved in development of human atherosclerosis describes an efficient model – one that the researchers say offers many applications for testing the potential effectiveness of new antioxidant and dietary therapies. …Read the full story from the UCSD Newsroom

Laboratory test tubes

Leader of the research team is Yury Miller, MD, PhD, associate professor of medicine in the Division of Endocrinology and Metabolism. His Department of Medicine coauthors include Joseph L. Witztum, MD, professor in the same division; and Sotirios “Sam” Tsimikas, MD, FACC, professor in the Division of Cardiology.   |   Read the article online in the Journal of Clinical Investigation.

In the Media: Dr. Sotirios Tsimikas

Dr. Sotirios “Sam” Tsimikas is featured in the story, “INNOVATION: From lab to product: a blood test’s story” in the North County Times.

Sotirios Tsimikas, M.D, is Professor of Clinical Medicine and Director of Vascular Medicine in the Division of Cardiology. He directs the Interventional Cardiology Fellowship Training Program.

To Prevent Heart Disease, Treat High Cholesterol Early in life, Dr. Daniel Steinberg and colleagues say

Early childhood is the time to start lowering cholesterol to prevent heart disease, according to Dr. Daniel Steinberg and colleagues at UCSD.

Daniel Steinberg, M.D., Ph.D., is Emeritus Professor of Medicine in the Division of Endocrinology & Metabolism. He is renowned for his groundbreaking research in cholesterol and atherosclerosis.

Read the full story from UC San Diego
Health Sciences Communications

His colleagues and co-authors, Christopher K. Glass, M.D., Ph.D., and Joseph Witztum, M.D., are both professors of medicine. All three researchers are members of the Division of Endocrinology & Metabolism.

Their analysis and recommendations are published in the August 5 issue of the journal Circulation.

Citation for the article:  Steinberg, Daniel MD, PhD; Glass, Christopher K. MD, PhD; Witztum, Joseph L. MD. Evidence Mandating Earlier and More Aggressive Treatment of Hypercholesterolemia. Circulation 2008 August 5;118(6):172-177. – |  Read the article (PDF)

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