Roche Funds Drug Discovery Projects at UC San Diego

The new UC San Diego-Roche Extending Innovation Network (EIN) program has been launched with selection of its first three research projects at the University of California, San Diego School of Medicine. The UC San Diego-Roche EIN program, which was formalized in June 2011, aims to accelerate the discovery of new drug therapies through research innovation at the interface of industry and academia. The program is slated to grow in the coming years as additional rounds of proposals are solicited. … Read the full story from the UCSD Newsroom

M. Geoffrey Rosenfeld, MD
M. Geoffrey Rosenfeld, MD (pictured above), is a co-investigator with Xiang-Dong Fu, PhD, on one of the three UC San Diego-Roche EIN-funded projects, in which the investigators will use genomic and RNA-based approaches to identify new drug targets.

Dr. Rosenfeld is Professor of Medicine in the Division of Endocrinology and Metabolism and a professor of the Howard Hughes Medical Institute. Dr. Fu is Professor of Cellular and Molecular Medicine and a member of the Institute for Genomic Medicine.

Biologists Use Flies and Mice to Get to the Heart of Down Syndrome

A novel study involving fruit flies and mice has allowed biologists to identify two critical genes responsible for congenital heart defects in individuals with Down syndrome, a major cause of infant mortality and death in people born with this genetic disorder. … Read the full story from the UCSD Newsroom


M. Geoff Rosenfeld, MD   Dr. Kirk Peterson

UC San Diego collaborators in this multi-center effort are Drs. Amir Gamliel, M. Geoff Rosenfeld and Kirk L. Peterson. M. Geoffrey Rosenfeld, MD, above left, is professor of medicine in the Division of Endocrinology and Metabolism and a Howard Hughes Medical Institute investigator.

Kirk Peterson, MD, FACP, FACC, above right, is director of the Sulpizio Cardiovascular Center, Edith and William M. Perlman Professor of Clinical Cardiology and professor of medicine in the Division of Cardiology.

Amir Gamliel, PhD, is a postdoctoral research scientist in the Department of Medicine.

Read the research report in PLoS Genetics (open access article).

Plasticity of Hormonal Response Permits Rapid Gene Expression Reprogramming

Gene expression reprogramming may allow cancer cell growth as well as normal differentiation

Gene expression is the process of converting the genetic information encoded in DNA into a final gene product such as a protein or any of several types of RNA. Scientists have long thought that the gene programs regulated by different physiological processes throughout the body are robustly pre-determined and relatively fixed for every specialized cell. But a new study by researchers from the University of California, San Diego School of Medicine reveals the unsuspected plasticity of some of these gene expression programs. … Read the full story from the UCSD Newsroom

M. Geoffrey Rosenfeld, MD

Co-principal investigator of the study is Dr. M. Geoffrey Rosenfeld (pictured at left). M. Geoffrey Rosenfeld, MD, is Professor of Medicine in the Division of Endocrinology and Metabolism and Howard Hughes Medical Institute investigator.

Department of Medicine coauthor Christopher K. Glass, MD, PhD, is Professor of Medicine in the Division of Endocrinology and Metabolism and Professor of Cellular and Molecular Medicine.

Read the published study in Nature (free full text).

Searching for the Soul of the Genome

The discovery that a “gene desert” on chromosome 9 was a hotspot for coronary artery disease (CAD) risk was among the highlights of findings produced recently by genome-wide association studies, which compare the genomes of many people for genetic variations and have been broadly used in the past few years to study hundreds of diseases and complex traits. Gene deserts are large genomic segments devoid of genes. … Read the full story from the UCSD Newsroom

One of the co-authors of the study report is M. Geoffrey Rosenfeld, M.D., pictured at left. Dr. Rosenfeld is Professor of Medicine in the Division of Endocrinology and Metabolism and Professor of the Howard Hughes Medical Institute.