Using microRNA Fit to a T (cell)

Researchers show B cells can deliver potentially therapeutic bits of modified RNA

Researchers at the University of California, San Diego School of Medicine have successfully targeted T lymphocytes – which play a central role in the body’s immune response – with another type of white blood cell engineered to synthesize and deliver bits of non-coding RNA or microRNA (miRNA). … Read the full story from the UC San Diego News Center


Dr. Maurizio ZanettiPrincipal investigator Maurizio Zanetti, MD, is emeritus professor of medicine in the Division of Hematology-Oncology and director of the Laboratory of Immunology at the UCSD Moores Cancer Center.

Dr. Zanetti is the director of tumor immunology for the UCSD Center for Immunology, Infection and Inflammation. He directs the immunology course in the Biomedical Sciences graduate program.

Citation for the study report in Proceedings of the National Academy of Sciences:

Gonzalo Almanza, Veronika Anufreichik, Jeffrey J. Rodvold, Kevin T. Chiu, Alexandra DeLaney, Johnny C. Akers, Clark C. Chen, and Maurizio Zanetti. Synthesis and delivery of short, noncoding RNA by B lymphocytes. PNAS 2013 ; published ahead of print November 25, 2013, doi:10.1073/pnas.1311145110  |  Abstract (Open access)  |  Full text (UCSD only)

Other UCSD news stories about Dr. Zanetti’s work:

Cancer Cells Co-opt Immune Response to Escape Destruction

Researchers at the University of California, San Diego School of Medicine report that tumor cells use stress signals to subvert responding immune cells, exploiting them to actually boost conditions beneficial to cancer growth. … Read the full story from the UCSD Newsroom


Dr. Maurizio ZanettiThe report comes from the laboratory of Dr. Maurizio Zanetti (left), with graduate student Navin R. Mahadevan as lead author and Dr. Zanetti as senior author.

Maurizio Zanetti, MD, is emeritus professor of medicine in the Division of Hematology-Oncology and director of the Laboratory of Immunology at the UCSD Moores Cancer Center.

Dr. Zanetti is the director of tumor immunology for the UCSD Center for Immunology, Infection and Inflammation.  He directs the immunology course in the Biomedical Sciences graduate program.

Drs. Zanetti and Mahadevan published a Science Magazine Perspectives article on the connection between immune surveillance and chromosomal chaos in September.

On the PLOS ONE report, coauthors from Dr. Zanetti’s laboratory are undergraduate student Veronika Anufreichik, graduate student Jeffrey J. Rodvold and research associate Kevin T. Chiu.

Read the report in PLOS ONE

Citation for the report:  Mahadevan NR, Anufreichik V, Rodvold JJ, Chiu KT, Sepulveda H, et al. (2012) Cell-Extrinsic Effects of Tumor ER Stress Imprint Myeloid Dendritic Cells and Impair CD8+ T Cell Priming. PLoS ONE 7(12): e51845. doi:10.1371/journal.pone.0051845

More Information:

  • Science Magazine Perspectives article, September 2012:

Zanetti M, Mahadevan NR. Immune Surveillance from Chromosomal Chaos? Science 337 (6102): 1616-1617, 28 September 2012. DOI: 10.1126/science.1228464.

  • Other UCSD news stories about Dr. Zanetti’s work:
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Call of the Riled

Stress Signal in Cancer Cells Triggers Similar Response in Other Cells, Aiding Tumor Growth

Researchers at the University of California, San Diego School of Medicine say a “stress response” mechanism used by normal cells to cope with harsh or demanding conditions is exploited by cancer cells, which transmit the same stress signal to surrounding cells, triggering an inflammatory response in them that can aid tumor growth…. Read the full story from the UCSD Newsroom


Dr. Maurizio ZanettiDr. Maurizio Zanetti, pictured at left, is senior author of the study. Maurizio Zanetti, MD, is Emeritus Professor of Medicine in the Division of Hematology-Oncology and Director of the Laboratory of Immunology at UC San Diego Moores Cancer Center|  Read the abstract of the published report in PNAS.