UC San Diego Researchers Develop Efficient Model for Generating Human Stem Cells

Approach has potential to simplify generation of iPSCs for use in human stem cell therapies

Researchers at the University of California, San Diego School of Medicine report a simple, easily reproducible RNA-based method of generating human induced pluripotent stem cells (iPSCs) in the August 1 edition of Cell Stem Cell. Their approach has broad applicability for the successful production of iPSCs for use in human stem cell studies and eventual cell therapies. … Read the full story from the UCSD Newsroom


Four Department of Medicine researchers are coauthors of the study report in Cell Stem Cell:

Citation for the study report: Naohisa Yoshioka, Edwige Gros, Hai-Ri Li, Shantanu Kumar, Dekker C. Deacon, Cornelia Maron, Alysson R. Muotri, Neil C. Chi, Xiang-Dong Fu, Benjamin D. Yu, Steven F. Dowdy. Efficient Generation of Human iPSCs by a Synthetic Self-Replicative RNA. Cell Stem Cell – 1 August 2013 (Vol. 13, Issue 2, pp. 246-254)  |  Read the report

Fate of the Heart: Researchers Track Cellular Events Leading to Cardiac Regeneration

Studies in zebrafish reveal abundant potential source for repair of injured heart muscle

In a study published in the June 19 online edition of the journal Nature, a scientific team led by researchers from the University of California, San Diego School of Medicine visually monitored the dynamic cellular events that take place when cardiac regeneration occurs in zebrafish after cardiac ventricular injury. Their findings provide evidence that various cell lines in the heart are more plastic, or capable of transformation into new cell types, than previously thought. … Read the full story from the UCSD Newsroom


Dr. Neil Chi

Dr. Neil Chi

Principal investigator of the study is Neil Chi, MD, PhD, assistant professor of medicine in the Division of Cardiology and member of the Institute for Genomic Medicine.

Chi directs the UC San Diego Cardiovascular Genetics Clinic and Cardiac Tissue Harvest and Biorepository Core.

In 2010, he received an NIH Director’s New Innovator Award for his study of cardiac regeneration in zebrafish. He is currently the principal investigator on that project and two R01 grant projects for research in cardiac morphogenesis and cardiac conduction development and disease.

Citation for the report: Zhang R, Han P, Yang H, Ouyang K, Lee D et al. In vivo cardiac reprogramming contributes to zebrafish heart regeneration. Nature (2013) doi:10.1038/nature12322.  |  Read the full text (UCSD only)

More Information About Dr. Chi: