The Connection Between Oxygen and Diabetes

A lack of O2 in fat cells triggers inflammation and insulin resistance in obesity:

Researchers at the University of California, San Diego School of Medicine have, for the first time, described the sequence of early cellular responses to a high-fat diet, one that can result in obesity-induced insulin resistance and diabetes. The findings, published in the June 5 issue of Cell, also suggest potential molecular targets for preventing or reversing the process.

Dr. Jerrold Olefsky“We’ve described the etiology of obesity-related diabetes. We’ve pinpointed the steps, the way the whole thing happens,” said Jerrold M. Olefsky, MD (left), associate dean for Scientific Affairs and Distinguished Professor of Medicine at UC San Diego. “The research is in mice, but the evidence suggests that the processes are comparable in humans and these findings are important to not just understanding how diabetes begins, but how better to treat and prevent it … Read the full story from the UC San Diego Newsroom

Immune Mechanism Blocks Inflammation Generated by Oxidative Stress

Potential therapeutic target for treating disorders like age-related macular degeneration

Conditions like atherosclerosis and age-related macular degeneration (AMD) – the most common cause of blindness among the elderly in western societies – are strongly linked to increased oxidative stress, the process in which proteins, lipids and DNA damaged by oxygen free radicals and related cellular waste accumulate, prompting an inflammatory response from the body’s innate immune system that results in chronic disease.

In the October 6, 2011 issue of Nature, researchers at the University of California, San Diego School of Medicine, as part of an international collaborative effort, identify a key protein… Read the full story from the UCSD Newsroom

Senior investigator Christoph J. Binder, MD, PhD, and coworkers report the results in the October 6, 2011, issue of Nature. Read the full text of the report

Dr. Binder is assistant professor of medicine at UC San Diego, principal investigator at the Center for Molecular Medicine of the Austrian Academy of Sciences and professor at the Medical University of Vienna.His Department of Medicine co-investigators are Joseph L. Witztum, MD, professor of medicine, and Karsten Hartvigsen, PhD, in the Division of Endocrinology and Metabolism and Sotirios Tsimikas, MD, professor of medicine and director of Vascular Medicine in the Division of Cardiology.