“Wildly Heterogeneous Genes”

New approach subtypes cancers by shared genetic effects; a step toward personalized medicine

Cancer tumors almost never share the exact same genetic mutations, a fact that has confounded scientific efforts to better categorize cancer types and develop more targeted, effective treatments.

In a paper published in the September 15 advanced online edition of Nature Methods, researchers at the University of California, San Diego propose a new approach called network-based stratification (NBS), which identifies cancer subtypes not by the singular mutations of individual patients, but by how those mutations affect shared genetic networks or systems. … Read the full story from the UCSD Newsroom


Trey Ideker, PhDLead investigator in the study is Trey Ideker, PhD, professor of medicine and bioengineering and chief of the Division of Medical Genetics in the Department of Medicine.

Postdoctoral researcher Hannah K. Carter and hematology/oncology fellow John P. Shen are the other Department of Medicine coauthors.

Citation for the study report:  Matan Hofree, John P Shen, Hannah Carter, Andrew Gross, Trey Ideker. Network-based stratification of tumor mutations. Nature Methods (2013) doi:10.1038/nmeth.2651. |  Full text (UCSD only)

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UC San Diego Health System and Qualcomm Life Join Forces to Improve Care Remotely

2net™ Platform provides physicians with state-of-the-art patient monitoring platform

UC San Diego Health System is collaborating with Qualcomm Life, a wholly owned subsidiary of Qualcomm Technologies, Inc. to pilot the 2net Platform and Hub for remote patient monitoring. Qualcomm Life’s innovative 2net™ technology collects patients’ clinical information from wireless medical devices and transmits it to UC San Diego Health System physicians, to supplement information already available. This system provides a rapid, automated way to collect patient data in near real-time, analyze the readings, and suggest follow up actions with the patient, if needed.. … Read the full story from the UCSD Newsroom


Marlene Millen, MDQuoted in the UCSD Newsroom story is Marlene Millen, MD, clinical service chief of the Internal Medicine Group and medical director of the Internal Medicine Group Hillcrest for UC San Diego Health System.

Dr. Millen and Dr. Deanna Hill, both primary care physicians in the Fourth & Lewis Medical Offices, are overseeing the pilot project. With the help of the clinic’s nurse case manager, they are reviewing the real-time data online and providing medical follow up with patients if needed.

While this is just a pilot project at present, Drs. Millen and Hill are hopeful that such monitoring will become a reality in patient care in the future.

Dr. Millen, pictured above left, is associate clinical professor in the Division of General Internal Medicine. She trained in internal medicine here at UCSD and was chief medical resident in 2004-2005.

In 2012, Dr. Millen was named on the “San Diego’s Top Doctors” list for the third straight year.

Dr. Deanna HillDr. Hill (left), a new member of the UC San Diego Health System faculty, is assistant clinical professor in the Division of General Internal Medicine. She is accepting new patients.

After her internship and residency training in internal medicine at UCLA, she spent two years at Yale-New Haven Hospital’s Primary Care Center before coming to UCSD.