Novel Approach Blocks Amyloid Production in Alzheimer’s Mouse Model

Promises potential early therapeutic intervention —

Offering a potential early intervention for Alzheimer’s disease (AD), researchers at University of California, San Diego School of Medicine and Cenna Biosciences, Inc. have identified compounds that block the production of beta amyloid peptides in mice. The study is reported April 29 in PLOS ONE.

If the results ultimately translate to human treatment, the most promising compound – a peptide dubbed P8 – could be administered to individuals at high risk of developing the disease, long before the tell-tale signs of dementia occur and perhaps with few side effects, due to the compound’s highly specific mode of action. … Read the full story from the UC San Diego Newsroom

California’s First Robotically Assisted Coronary Stenting Procedure Performed at UC San Diego Sulpizio Cardiovascular Center

Technology Improves Accuracy of Device Placement and Patient Outcomes

The interventional cardiology team led by Ehtisham Mahmud, MD, FACC, at UC San Diego Sulpizio Cardiovascular Center (SCVC) has successfully completed the first two robotically-assisted coronary angioplasty/stent procedures in California. Patients with coronary artery disease (CAD) now have access to this new technology that puts the precision of a robot in the hands of interventional cardiologists during procedures to open clogged heart arteries. … Read the full story from the UC San Diego News Center

Testing Antioxidant Drugs is Transparent

A study using genetically modified zebrafish to visualize early events involved in development of human atherosclerosis describes an efficient model – one that the researchers say offers many applications for testing the potential effectiveness of new antioxidant and dietary therapies. …Read the full story from the UCSD Newsroom

Laboratory test tubes

Leader of the research team is Yury Miller, MD, PhD, associate professor of medicine in the Division of Endocrinology and Metabolism. His Department of Medicine coauthors include Joseph L. Witztum, MD, professor in the same division; and Sotirios “Sam” Tsimikas, MD, FACC, professor in the Division of Cardiology.   |   Read the article online in the Journal of Clinical Investigation.