Researchers Find Link Between Inflammation, Tissue Regeneration and Wound Repair Response

Discovery has implications for potential new treatments of some cancers and inflammatory bowel disease —

Almost all injuries, even minor skin scratches, trigger an inflammatory response, which provides protection against invading microbes but also turns on regenerative signals needed for healing and injury repair – a process that is generally understood but remains mysterious in its particulars.

Writing in the February 25 online issue of Nature, an international team of scientists, headed by researchers at the University of California, San Diego School of Medicine, report finding new links between inflammation and regeneration: signaling pathways that are activated by a receptor protein called gp130.. … Read the full story from the UC San Diego Newsroom

Dr. William SandbornStudy coinvestigators included Division of Gastroenterology division chief William Sandborn, MD, and Inflammatory Disease Center researchers Brigid S. Boland and John T. Chang.

Other Department of Medicine coauthors included Petrus R. de Jong; and Samuel B. Ho, professor of medicine in the Division of Gastroenterology and Section Chief, Gastroenterology, at the VA San Diego Healthcare System.

Full text of the article (UC San Diego only)

Fate of the Heart: Researchers Track Cellular Events Leading to Cardiac Regeneration

Studies in zebrafish reveal abundant potential source for repair of injured heart muscle

In a study published in the June 19 online edition of the journal Nature, a scientific team led by researchers from the University of California, San Diego School of Medicine visually monitored the dynamic cellular events that take place when cardiac regeneration occurs in zebrafish after cardiac ventricular injury. Their findings provide evidence that various cell lines in the heart are more plastic, or capable of transformation into new cell types, than previously thought. … Read the full story from the UCSD Newsroom

Dr. Neil Chi

Dr. Neil Chi

Principal investigator of the study is Neil Chi, MD, PhD, assistant professor of medicine in the Division of Cardiology and member of the Institute for Genomic Medicine.

Chi directs the UC San Diego Cardiovascular Genetics Clinic and Cardiac Tissue Harvest and Biorepository Core.

In 2010, he received an NIH Director’s New Innovator Award for his study of cardiac regeneration in zebrafish. He is currently the principal investigator on that project and two R01 grant projects for research in cardiac morphogenesis and cardiac conduction development and disease.

Citation for the report: Zhang R, Han P, Yang H, Ouyang K, Lee D et al. In vivo cardiac reprogramming contributes to zebrafish heart regeneration. Nature (2013) doi:10.1038/nature12322.  |  Read the full text (UCSD only)

More Information About Dr. Chi:

DNA Mismatch Repair Happens Only During A Brief Window of Opportunity

In eukaryotes – the group of organisms that include humans – a key to survival is the ability of certain proteins to quickly and accurately repair genetic errors that occur when DNA is replicated to make new cells.

In a paper published in the December 23, 2011 issue of the journal Science, researchers at the Ludwig Institute for Cancer Research and the University of California, San Diego School of Medicine have solved part of the mystery of how these proteins do their job… Read the full story from the UCSD Newsroom

The new findings come from the Laboratory of Cancer Genetics in the San Diego branch of the Ludwig Institute for Cancer Research, the departments of Medicine and Cellular and Molecular Medicine, the Moores Cancer Center, and the Institute for Genomic Medicine in the UCSD School of Medicine.

Senior investigator Richard D. Kolodner, PhD, head of the Laboratory of Cancer Genetics, is a professor in the departments of Medicine and Cellular and Molecular Medicine. First author Christopher D. Putnam, PhD, is assistant professor of medicine and coauthors Hans Hombauer and Anjana Srivatsan are postdoctoral fellows in the Kolodner laboratory.

Read the study report in Science