Spotting the Earliest Signs of Type 1 Diabetic Kidney Disease

JDRF network grant to fund study to find new types of diagnostic markers —

In an effort to pinpoint the earliest signs of diabetic kidney disease, researchers at University of California, San Diego School of Medicine are leading a multi-institutional international effort dedicated to finding a new breed of disease indicators.

The study, funded by a $2.5 million JDRF (formerly known as the Juvenile Diabetes Research Foundation) grant, will tap the potential of three emerging “omics” sciences to discover new ways to determine which patients are most likely to develop diabetic kidney disease. Samples from more than 2,000 type 1 diabetes patients, collected over a period of years by several medical centers around the world, will be used in the analyses. …Read the full story from the UC San Diego Newsroom


Kumar Sharma, MD, FAHAPrincipal investigator of the study is Kumar Sharma, MD, FAHA, Professor of Medicine in the Division of Nephrology. He directs the Center for Renal Translational Medicine and the Institute of Metabolomic Medicine in UC San Diego School of Medicine.

Global Public Health Division Video Wins 2nd Prize in Video Challenge Competition for UC Global Health Day

A video made by doctoral candidate Jaime Arredondo and other members of the Division of Global Public Health has won second prize in the Video Challenge Competition for UC Global Health Day.

The video, “The Forgotten: Clinica del Bordo,” takes viewers to the San Diego-Tijuana border, where Arredondo and many other members of the global public health division provide wound care, HIV testing and other basic health services to people who live in the Tijuana River Canal.

Canal Wound Clinic, or Clinica del Bordo, is an outreach effort of UC San Diego’s NIDA-funded Proyecto el Cuete IV program, Impact of Drug Policy Reform on the HIV Risk Environment Among IDUs in Tijuana.

“This brief video embodies our division’s philosophy of integrating research, training and service to improve the health of our border community,” said Division of Global Public Health chief Steffanie Strathdee, PhD.

“I am very proud that our work is upheld by our students, as they are our next generation of health providers and prevention scientists.”

Dr. Strathdee is Harold Simon Professor, Associate Dean of Global Health Sciences; Chief, Division of Global Public Health and Director of the UC San Diego Global Health Initiative.

Jaime Arredondo is an AIDS International Training and Research (AITRP) fellow.

The video is here:

Pepper and Halt: Spicy Chemical May Inhibit Gut Tumors

Researchers at the University of California, San Diego School of Medicine report that dietary capsaicin – the active ingredient in chili peppers – produces chronic activation of a receptor on cells lining the intestines of mice, triggering a reaction that ultimately reduces the risk of colorectal tumors.

The findings are published in the August 1, 2014 issue of The Journal of Clinical InvestigationRead the full story from the UCSD Newsroom


Eyal Raz, MD

Eyal Raz, MD

Senior author of the study is Eyal Raz, MD, professor of medicine in the Division of Rheumatology, Allergy and Immunology.

Dr. Lars Eckmann

Lars Eckmann, MD

Department of Medicine faculty coauthors include Lars Eckmann, MD, right, professor of medicine, and Hui Dong, MD, PhD, associate professor, both in the Division of Gastroenterology; and Maripat Corr, MD, professor of medicine in the Division of Rheumatology, Allergy & Immunology.

Maripat Corr, MD

Maripat Corr, MD

HIV Transmission Networks Mapped to Reduce Infection Rate

Researchers at the University of California, San Diego School of Medicine have mapped the transmission network of human immunodeficiency virus (HIV) in San Diego. The mapping of HIV infections, which used genetic sequencing, allowed researchers to predictively model the likelihood of new HIV transmissions and identify persons at greatest risk for transmitting the virus. … Read the full story from the UC San Diego Newsroom

Kawasaki Disease and Pregnant Women

UC San Diego researchers say risks are manageable, provided doctors recognize them

In the first study of its type, researchers at the University of California, San Diego School of Medicine have looked at the health threat to pregnant women with a history of Kawasaki disease (KD), concluding that the risks are low with informed management and care.

The findings are published in the March 6, 2014 online edition of the British Journal of Obstetrics and Gynaecology. …Read the full story from the UC San Diego News Center


Dr. Lori DanielsDepartment of Medicine faculty members Lori B. Daniels, MD, right, and Andrew M. Kahn, MD, PhD, were investigators in the study.

Both are associate clinical professors in the Division of Cardiovascular Medicine.

The Role of “Master Regulators” in Gene Mutations and Disease

Researchers identify key proteins that help establish cell function

Researchers at the University of California, San Diego School of Medicine have developed a new way to parse and understand how special proteins called “master regulators” read the genome, and consequently turn genes on and off. … Read the full story from the UC San Diego News Center


Christopher K. Glass, MD, PhDThe principal investigator of the reported study is Christopher K. Glass, MD, PhD, professor of medicine in the Division of Endocrinology & Metabolism and professor of cellular and molecular medicine at UC San Diego.

He is on the faculty of the UC San Diego Institute for Genomic Medicine.

Visit the Glass Laboratory website.

Related UC San Diego news stories:

Checkup Diabetes: the Latest Research and Treatments from UC San Diego

News Feature from the UC San Diego Health System Newsroom

Checkup Diabetes: the latest research and treatments at UC San Diego

by Scott LaFee

Diabetes is a monumental public health issue, not just because millions of Americans have been diagnosed with the metabolic disease, but also for the many more millions who either remain undiagnosed or have signs suggesting they will likely become diabetic. .. Read the full news feature from the UC San Diego Health System newsroom

Vitamin D Deficiency Linked to Type 1 Diabetes

 

A study led by researchers from the University of California, San Diego School of Medicine has found a correlation between vitamin D3 serum levels and subsequent incidence of Type 1 diabetes.  The six-year study of blood levels of nearly 2,000 individuals suggests a preventive role for vitamin D3 in this disease.  The research appears the December issue of Diabetologia, a publication of the European Association for the Study of Diabetes (EASD). … Read the full story from the UCSD Newsroom


Heather Hofflich, DOHeather Hofflich, DO, Health Sciences associate clinical professor in the Division of General Internal Medicine, is a coauthor of the report.

Citation for the report: Gorham ED, Garland CF, Burgi AA, Mohr SB, Zeng K, Hofflich H, Kim JJ, Ricordi C. Lower prediagnostic serum 25-hydroxyvitamin D concentration is associated with higher risk of insulin-requiring diabetes: a nested case–control study. Diabetologia 2012; 55:3224–3227. DOI: 10.1007/s00125-012-2709-8. Epub 2012 Sep 7. PMID:22955995.

Potency of Statins Linked to Muscle Side Effects

A study from the University of California, San Diego School of Medicine, published August 22 online by PLoS ONE, reports that muscle problems reported by patients taking statins were related to the strength or potency of the given cholesterol-lowering drugs. … Read the full story from the UCSD Newsroom


Dr. Beatrice Golomb led the study team. Beatrice Golomb, MD, PhD, is professor of medicine in the Division of General Internal Medicine.More information:

  • Citation for the new study: Hoffman KB, Kraus C, Dimbil M, Golomb BA. A survey of the FDA’s AERS database regarding muscle and tendon adverse events linked to the statin drug class. PLoS One. 2012;7(8):e42866. doi: 10.1371/journal.pone.0042866. Epub 2012 Aug 22. Abstract
  • Related study: Statins Shown to Cause Fatigue

Matters of the Heart: A Q&A with Ehtisham Mahmud

News Feature from the UC San Diego Health System Newsroom

Matters of the Heart: A Q&A with Ehtisham Mahmud
A profile of Dr. Ehtisham Mahmud
Professor and Chief of Cardiovascular Medicine
Co-director of UC San Diego Sulpizio Cardiovascular Center
Director, Interventional Cardiology and Cardiac Catheterization Laboratory

by Scott LaFee

Every 34 seconds, on average, an American has a heart attack. Every minute, someone in the United States dies from a heart disease-related event. Both men and women are afflicted equally, if differently. More than one-quarter of the annual deaths in this country are due to cardiovascular disease in its myriad manifestations. It claims more lives each year than cancer, chronic lower respiratory diseases and accidents combined.”… Read the full profile from the UC San Diego Health System newsroom