$100 Million Gift Launches Sanford Stem Cell Clinical Center

UC San Diego-based effort will speed discoveries to new drugs and treatments for patients

Dr. Catriona Jamieson

In a bold and singular step toward delivering the therapeutic promise of human stem cells, businessman and philanthropist T. Denny Sanford has committed $100 million to the creation of the Sanford Stem Cell Clinical Center at the University of California, San Diego… Read the full story from the UC San Diego News Center

Pictured: Catriona H. M. Jamieson, MD, PhD, associate professor of medicine in the Division of Hematology-Oncology and director of stem cell research at the UC San Diego Moores Cancer Center.

New Cancer Council Combines Local Centers’ Strengths

UC San Diego Moores Cancer Center, Salk Institute for Biological Studies and Sanford-Burnham Medical Research Institute come together in novel collaboration

San Diego is a powerhouse for cancer research, home to the University of California, San Diego Moores Cancer Center – the region’s only National Cancer Institute (NCI)-designated comprehensive cancer center – and two NCI-designated centers for basic research: the Salk Institute Cancer Center and the Cancer Center at Sanford-Burnham Medical Research Institute.

These singular enterprises have now formed a novel collaboration – the San Diego National Cancer Institute Cancer Centers Council, or C3 – to leverage their distinct and combined resources and talents. … Read the full story from the UCSD Newsroom


UC San Diego Moores Cancer Center

Dr. Scott Lippman Senior UC San Diego Moores Cancer Center leaders and Department of Medicine professors Scott Lippman, MD, and Barbara Parker, MD, are voting members of the new NCI Cancer Centers Council (C3).

Lippman is director and Chugai Pharmaceutical Chair, UC San Diego Moores Cancer Center and senior associate dean and assistant vice chancellor for Cancer Research and Care, UC San Diego.

Barbara A. Parker, MDParker is professor of clinical medicine, UCSD School of Medicine and deputy director for Clinical Affairs, UCSD Moores Cancer Center.

She received her internal medicine residency training, served as chief medical resident and did her hematology-oncology fellowship at UC San Diego.

Lippman is professor of medicine and Parker is professor of clinical medicine in the Division of Hematology-Oncology.

Drug Targets Hard-to-Reach Leukemia Stem Cells Responsible for Relapses

Researchers at the University of California, San Diego School of Medicine have discovered that hard-to-reach, drug-resistant leukemia stem cells (LSCs) that overexpress multiple pro-survival protein forms are sensitive – and thus vulnerable – to a novel cancer stem cell-targeting drug currently under development. … Read the full story from the UCSD Newsroom


Catriona H. M. Jamieson, MD, PhDPrincipal investigator of the study is Catriona H. M. Jamieson, MD, PhD, associate professor of medicine in the Division of Hematology-Oncology and director of stem cell research at the UC San Diego Moores Cancer Center.

Dr. Jamieson is on the steering committee for the Moores Cancer Center’s My Answer to Cancer initiative for personalized cancer therapy. She is a member of the faculty in the UCSD Biomedical Sciences Graduate Program.

Citation for the report: Goff DJ, Recart AC, Sadarangani A, Chun H-J, Barrett CL, Krajewska M, Leu H, Low-Marchelli J, Ma W, Shih AY, Wei J, Zhai D, Geron I, Pu M, Bao L, Chuang R, Balaian L, Gotlib J, Minden M, Martinelli G, Rusert J, Dao K-H, Shazand K, Wentworth P, Smith KM, Jamieson CAM, Morris SR, Messer K, S.B. Goldstein LSB, Hudson TJ, Marra M, Frazer KA, Pellecchia M, Reed JC, and Jamieson CHM. (2013) A Pan-BCL2 Inhibitor Renders Bone-Marrow-Resident Human Leukemia Stem Cells Sensitive to Tyrosine Kinase Inhibition. Cell Stem Cell 10.1016/j.stem.2012.12.011, online January 17, 2013.

More about Dr. Jamieson and her work:

Biologists Use Flies and Mice to Get to the Heart of Down Syndrome

A novel study involving fruit flies and mice has allowed biologists to identify two critical genes responsible for congenital heart defects in individuals with Down syndrome, a major cause of infant mortality and death in people born with this genetic disorder. … Read the full story from the UCSD Newsroom


M. Geoff Rosenfeld, MD   Dr. Kirk Peterson

UC San Diego collaborators in this multi-center effort are Drs. Amir Gamliel, M. Geoff Rosenfeld and Kirk L. Peterson. M. Geoffrey Rosenfeld, MD, above left, is professor of medicine in the Division of Endocrinology and Metabolism and a Howard Hughes Medical Institute investigator.

Kirk Peterson, MD, FACP, FACC, above right, is director of the Sulpizio Cardiovascular Center, Edith and William M. Perlman Professor of Clinical Cardiology and professor of medicine in the Division of Cardiology.

Amir Gamliel, PhD, is a postdoctoral research scientist in the Department of Medicine.

Read the research report in PLoS Genetics (open access article).