New Findings on Fat Cell Metabolism Could Lead to New Approaches for Treating Diabetes and Obesity

November 17, 2015

Researchers at the University of California, San Diego report new insights into what nutrients fat cells metabolize to make fatty acids. The findings pave the way for understanding potential irregularities in fat cell metabolism that occur in patients with diabetes and obesity and could lead to new treatments for these conditions. The researchers published their findings online in the Nov. 16 issue of Nature Chemical Biology…. Read the full story from the UC San Diego Newsroom

Dr. Trey Ideker Named AAAS Fellow

Trey Ideker, PhD

Trey Ideker, PhD

Trey Ideker, PhD, professor of medicine in the Division of Medical Genetics and professor of bioengineering, is one of three UC San Diego faculty members to be named Fellow of the American Association for the Advancement of Science (AAAS) this year. …Read the full story from the UC San Diego Newsroom.

 

Dr. Catriona Jamieson Announced as Inaugural Chief of New Division of Regenerative Medicine

Announced today by Wolfgang H. Dillmann, MD, Helen M. Ranney Distinguished Professor and Chair of the Department of Medicine

Catriona H. M. Jamieson, MD, PhD

Catriona Jamieson, MD, PhD

Please join me in officially welcoming Catriona Jamieson, MD, PhD, as the inaugural chief of the new Division of Regenerative Medicine. The Department of Medicine is delighted to announce the inception of the Division of Regenerative Medicine and we enthusiastically support Dr. Jamieson’s talent and vision for this innovative endeavor.

Wolfgang H. Dillmann, MD

Wolfgang H. Dillmann, MD

Dr. Jamieson joined the UC San Diego faculty in 2005 and is an associate professor of Medicine in the Division of Hematology-Oncology. She has proven her leadership skills, expertise and effectiveness in her current positions as director of the Stem Cell Research Program at Moores Cancer Center, co-leader of the Hematologic Malignancies Program, hematology team leader, co-director of the UC San Diego Stem Cell Training Grant, coordinating course director of the Interdisciplinary Stem Cell course, and a co-director of the new Sanford Stem Cell Clinical Center.

Dr. Jamieson received her medical and doctorate degrees from the University of British Columbia. She completed her residency and clinical fellowships in bone marrow transplantation and hematology, as well as her postdoctoral research fellowship in the laboratory of Professor Irving Weissman at Stanford.

As a physician-scientist, Dr. Jamieson specializes in leukemia and myeloproliferative neoplasms, which are a family of uncommon, but not rare, degenerative disorders in which the body overproduces blood cells. These disorders can cause blood clotting which can lead to heart attack, stroke, and other life-threatening complications including transformation to acute leukemia. Dr. Jamieson’s research focuses on the mutant stem cells and progenitor cells in myeloproliferative neoplasms, which can give rise to cancer stem cells. Her stem-cell research studies have taken a substantial leap from identifying a promising treatment in the laboratory to completing the first clinical trial targeting cancer stem cells in humans. Her discoveries in myeloproliferative neoplasms are now being brought together with a drug development track of a regional pharmaceutical company.

Please join me in giving your enthusiastic support to Dr. Jamieson in her new leadership role as the inaugural chief of the Division of Regenerative Medicine here at UC San Diego. This is a unique and exciting opportunity to make UC San Diego a key hub for the rapid translation of stem cell discoveries to the clinic.

University of California Launches its First Tool for Data Sharing Among Medical Centers with UC Research eXchange

Announcement for UC Investigators

Gary S. Firestein, MD
Chair, University of California Biomedical Research
Acceleration, Integration and Development (UCBRAID)
Professor of Medicine
Dean and Associate Vice Chancellor, Translational Medicine
Director, Clinical and Translational Research Institute
UC San Diego

Dr. Gary Firestein

Dr. Gary Firestein, UC BRAID Chair

The University of California Biomedical Research Acceleration, Integration and Development (UC BRAID; ucbraid.org) is pleased to announce the launch of the UC Research eXchange (UC ReX) and the UC ReX Data Explorer tool. This system enables exploration of a combined population of over 12 million patients from medical center databases at UC Los Angeles, UC Irvine, UC Davis, UC San Diego, and UC San Francisco.

UC ReX Data Explorer gives researchers and quality specialists access to cohort counts derived from de-identified clinical data collected at the point of care to improve medical care and advance research.

UC ReX was initiated by UC BRAID in 2011 with a 5-year grant of $5 million from the UC Office of the President (UCOP) and developed through a collaboration of the medical campuses and their Chief Information Officers and CTSAs.

An important part of UC BRAID’s mission is to improve UC collaborative research opportunities. UC ReX is a great example of how UC BRAID facilitates integration of research programs, clinical informatics, technology, and resources across University of California campuses.

To start exploring UC ReX with Data Explorer, please go to ucrex.org for more information.  |  See UC ReX Flier

Access UC-ReX via UC San Diego Clinical and Translational Research Institute

 

Seema Sharma Aceves MD, PhD, Elected to American Society for Clinical Investigation

Dr. Seema S. AcevesUC San Diego pediatric allergy/immunology physician-scientist Seema Sharma Aceves, MD, PhD, has been elected to the American Society for Clinical Investigation (ASCI).

She was formally inducted into the Society in a ceremony at the ASCI annual meeting in Chicago on April 26.

“It is a true honor to be included in this distinguished group of translational research leaders,” Aceves said.

“Seema represents the best and the brightest among clinical investigators today,” said Gary S. Firestein, MD, who nominated her for the honor.

“Her remarkable progress understanding the causes of an unusual and very debilitating disease in children made a significant impact on their quality of life.”

Firestein is professor of medicine in the Division of Rheumatology, Allergy & Immunology, Dean of Translational Medicine, Associate Vice Chancellor of Translational Medicine and director of the Clinical and Translational Research Institute.

Aceves, a specialist in pediatric eosinophilic esophagitis (EoE), is associate professor of clinical medicine in the Division of Rheumatology, Allergy & Immunology and associate professor of pediatrics in the Division of Allergy-Immunology-Rheumatology.

In her research, she investigates the mechanisms of tissue remodeling in EoE, exploring the role of pro-inflammatory and pro-fibrotic molecules. Major support for her work comes from a National Institutes of Health R01 research grant and funding from the Department of Defense.  |  Read NIH grant abstract

Her clinical specialty is pediatric allergy (Rady Children’s Specialists of San Diego). She practices at Rady Children’s Hospital – San Diego, where she directs the Eosinophilic Gastrointestinal Disorders Clinic.

Aceves received all of her medical training at UC San Diego. After she earned her MD and PhD in the Medical Scientist Training Program, she completed her internship and residency in the Department of Pediatrics and her fellowship training in allergy and immunology in the Department of Medicine.

She is board certified in allergy/immunology and pediatric allergy/immunology.

She was named a Physician of Exceptional Excellence in the 2012-2013 “San Diego’s Top Doctors” survey from the San Diego County Medical Society and San Diego Magazine and listed as one of the nation’s top doctors on the 2012-2013 U.S.News & World Report “Top Doctors” List.

Dr. David Brenner Speaking at Grand Rounds March 13

David A. Brenner, MD Speaking at Medicine Grand Rounds on March 13 is Dr. David A. Brenner, vice chancellor for health sciences, dean of the UCSD School of Medicine and professor of medicine in the Division of Gastroenterology.

A physician-scientist, Brenner is widely respected for his translational research in liver disease. He will speak at Grand Rounds on new approaches to therapy for fibrosis.

Brenner is a member of numerous honorific societies including the American Society of Clinical Investigation, the American College of Physicians and the Association of American Physicians, of which he is immediate Past President. Last year, he was elected to the Institute of Medicine.

UC San Diego press releases about his recent research:

Read Dr. Brenner’s School of Medicine Biography

About Medicine Grand Rounds

UCSD’s Medicine Grand Rounds is held weekly on Wednesday mornings, 7:30 – 8:30 a.m., in the Liebow Auditorium, second floor, Biomedical Sciences Building on the UCSD School of Medicine Campus. There is a hiatus in summer.

To see this year’s schedule and find video viewing information, visit the Medicine Grand Rounds page on the Department of Medicine website.

Scarring Cells Revert to Inactive State As Liver Heals

Research with mice reveals possible strategy to reverse fibrosis in liver and other organs

An international team of scientists, led by researchers at the University of California, San Diego School of Medicine, report that significant numbers of myofibroblasts – cells that produce the fibrous scarring in chronic liver injury – revert to an inactive phenotype as the liver heals. The discovery in mouse models could ultimately help lead to new human therapies for reversing fibrosis in the liver, and in other organs like the lungs and kidneys…. Read the full story from the UCSD Newsroom


Dr. David A. Brenner
Senior author of the study report is David A. Brenner, MD, vice chancellor for Health Sciences, dean of the UC San Diego School of Medicine and professor of medicine in the Division of Gastroenterology.

Among the coauthors is Wolfgang H. Dillmann, MD, Helen M. Ranney Professor and Chair, Department of Medicine and translational researcher in the Division of Endocrinology and Metabolism.

Scott M. Lippman, MD, Named New Director of UC San Diego Moores Cancer Center

Scott M. Lippman, MD, chair of Thoracic/Head and Neck Medical Oncology at The University of Texas (UT) MD Anderson Cancer Center, has accepted the position of director of Moores Cancer Center at the University of California, San Diego, beginning May 1, 2012…. Read the full story from the UCSD Newsroom

Roche Funds Drug Discovery Projects at UC San Diego

The new UC San Diego-Roche Extending Innovation Network (EIN) program has been launched with selection of its first three research projects at the University of California, San Diego School of Medicine. The UC San Diego-Roche EIN program, which was formalized in June 2011, aims to accelerate the discovery of new drug therapies through research innovation at the interface of industry and academia. The program is slated to grow in the coming years as additional rounds of proposals are solicited. … Read the full story from the UCSD Newsroom

M. Geoffrey Rosenfeld, MD
M. Geoffrey Rosenfeld, MD (pictured above), is a co-investigator with Xiang-Dong Fu, PhD, on one of the three UC San Diego-Roche EIN-funded projects, in which the investigators will use genomic and RNA-based approaches to identify new drug targets.

Dr. Rosenfeld is Professor of Medicine in the Division of Endocrinology and Metabolism and a professor of the Howard Hughes Medical Institute. Dr. Fu is Professor of Cellular and Molecular Medicine and a member of the Institute for Genomic Medicine.

A Rich, Collaborative Environment Advances Patient Care

UC San Diego Health Sciences has entered a period of remarkable growth, one that will strengthen its position as a destination academic medical center. In addition to the recent addition of the Sulpizio Cardiovascular Center and Medical Education & Telemedicine Building, plans are underway for the Altman Clinical and Translational Research Institute building… Read the full story from the UCSD Newsroom