Protein’s Impact on Colorectal Cancer is Dappled

In early stages, it acts as tumor suppressor; later it can help spread disease —

Researchers at University of California, San Diego School of Medicine have discovered a cell signaling pathway that appears to exert some control over initiation and progression of colorectal cancer, the third leading cause of cancer-related death in the United States. A key protein in the pathway also appears to be predictive of cancer survival rates. … Read the full story from the UC San Diego Newsroom


Dr. Pradipta GhoshThe study’s senior author is Pradipta Ghosh, MD, associate professor of medicine in the Division of Gastroenterology.

Pepper and Halt: Spicy Chemical May Inhibit Gut Tumors

Researchers at the University of California, San Diego School of Medicine report that dietary capsaicin – the active ingredient in chili peppers – produces chronic activation of a receptor on cells lining the intestines of mice, triggering a reaction that ultimately reduces the risk of colorectal tumors.

The findings are published in the August 1, 2014 issue of The Journal of Clinical InvestigationRead the full story from the UCSD Newsroom


Eyal Raz, MD

Eyal Raz, MD

Senior author of the study is Eyal Raz, MD, professor of medicine in the Division of Rheumatology, Allergy and Immunology.

Dr. Lars Eckmann

Lars Eckmann, MD

Department of Medicine faculty coauthors include Lars Eckmann, MD, right, professor of medicine, and Hui Dong, MD, PhD, associate professor, both in the Division of Gastroenterology; and Maripat Corr, MD, professor of medicine in the Division of Rheumatology, Allergy & Immunology.

Maripat Corr, MD

Maripat Corr, MD