UC San Diego Endocrinologists Team with Pharmacists to Offer Diabetes “Tune Up” Clinic

Dr. Steven Edelman

Dr. Steven Edelman

Department of Medicine endocrinologists Steven V. Edelman, MD, (left) and Robert R. Henry, MD (below right), collaborate with Candis Morello, Pharm D, and students in the Skaggs School of Pharmacy and Pharmaceutical Sciences to offer a six-month Diabetes Intensive Medical Management (DIMM) “tune up” clinic for patients with complex cases of diabetes at the VA San Diego Healthcare System.

Dr. Robert Henry

Dr. Robert Henry

At each visit, a patient receives an hour of personalized attention to medication management, diet, exercise, controlling blood sugar levels and other necessities that may be involved in a complex case of diabetes.

The aim is to achieve glycemic control within the six-month period of the “tune up” clinic..

In a preliminary study, Drs. Morello, Evans, Henry and coworkers have assessed the outcomes of the clinic, and the findings indicate that this pharmacist-endocrinologist collaborative approach is effective.  |  Read the Study Abstract in the January 2016 issue of Annals of Pharmacotherapy  |  Read the full story from the UC San Diego Newsroom

Steven V. Edelman, MD, Clinical Professor in the Department of Medicine, directs the Diabetes Care Clinic at VA San Diego Healthcare System (VASDHS) and is an investigator in the VA Center for Metabolic Research. He is founder and director of Taking Control of Your Diabetes, a non-profit diabetes education organization. He conducts research focusing on developing and evaluating new treatments for type 1 and type 2 diabetes.

Robert R. Henry, MD, Professor in the Department of Medicine, is Chief of the VA Center for Metabolic Research and Chief of the Section of Endocrinology, Metabolism and Diabetes at VASDHS. In his research, he investigates the etiology, treatment, and prevention of obesity and type 2 diabetes.

Dr. Morello is Professor of Clinical Pharmacy and Associate Dean for Student Affairs at Skaggs School of Pharmacy and Pharmaceutical Sciences.

The study report was published online in November, 2015, and in print in January, 2016.

Spotting the Earliest Signs of Type 1 Diabetic Kidney Disease

JDRF network grant to fund study to find new types of diagnostic markers —

In an effort to pinpoint the earliest signs of diabetic kidney disease, researchers at University of California, San Diego School of Medicine are leading a multi-institutional international effort dedicated to finding a new breed of disease indicators.

The study, funded by a $2.5 million JDRF (formerly known as the Juvenile Diabetes Research Foundation) grant, will tap the potential of three emerging “omics” sciences to discover new ways to determine which patients are most likely to develop diabetic kidney disease. Samples from more than 2,000 type 1 diabetes patients, collected over a period of years by several medical centers around the world, will be used in the analyses. …Read the full story from the UC San Diego Newsroom


Kumar Sharma, MD, FAHAPrincipal investigator of the study is Kumar Sharma, MD, FAHA, Professor of Medicine in the Division of Nephrology. He directs the Center for Renal Translational Medicine and the Institute of Metabolomic Medicine in UC San Diego School of Medicine.

UC San Diego Named Stem Cell “Alpha Clinic”

Designation will help speed development of emerging drugs and therapies —

In a push to further speed clinical development of emerging stem cell therapies, Sanford Stem Cell Clinical Center at UC San Diego Health System was named today one of three new “alpha clinics” by the California Institute for Regenerative Medicine (CIRM), the state’s stem cell agency.

The announcement, made at a public meeting in Los Angeles of the CIRM Governing Board, includes an award of $8 million for each of three sites. The other alpha grant recipients are the City of Hope hospital near Los Angeles and University of California, Los Angeles.

“A UC San Diego alpha clinic will provide vital infrastructure for establishing a comprehensive regenerative medicine clinical hub that can support the unusual complexity of first-in-human stem cell-related clinical trials,” said Catriona Jamieson, MD, PhD, associate professor of medicine at UC San Diego School of Medicine, deputy director of the Sanford Stem Cell Clinical Center, director of the UC San Diego Moores Cancer Center stem cell program and the alpha clinic grant’s principal investigator. … Read the Full Story from the UC San Diego Health Newsroom

Clinical Trial To Test Safety of Stem Cell-Derived Therapy for Type 1 Diabetes

UC San Diego is initial site for first-in-human testing of implanted cell therapy

Researchers at the University of California, San Diego School of Medicine, in partnership with ViaCyte, Inc., a San Diego-based biotechnology firm specializing in regenerative medicine, have launched the first-ever human Phase I/II clinical trial of a stem cell-derived therapy for patients with Type 1 diabetes. … Read the full story from the UCSD Newsroom


Principal investigator in the study is Robert R. Henry, MD, professor of medicine in the Division of Endocrinology and Metabolism at UC San Diego and chief of the Section of Endocrinology, Metabolism & Diabetes at the Veterans Affairs San Diego Healthcare System.

Enzyme Restores Function with Diabetic Kidney Disease

Mouse findings reverse prevailing theory; point to potential treatment options

Researchers at the University of California, San Diego School of Medicine say that, while a prevailing theory suggests elevated cellular levels of glucose ultimately result in diabetic kidney disease, the truth may, in fact, be quite the opposite. The findings could fundamentally change understanding of how diabetes-related diseases develop – and how they might be better treated. … Read the full story from the UC San Diego News Center


Kumar Sharma, MD, FAHA Kumar Sharma, MD, FAHA, senior author of the study report, is professor of medicine and director of the Center for Renal Translational Medicine in the Division of Nephrology-Hypertension.

Dr. Laura DuganFirst author Laura L. Dugan, MD, at right, is professor of neurosciences and professor and chief of the Division of Geriatrics in the Department of Medicine. She holds the Larry L. Hillblom Chair in Geriatric Medicine.

Second author Young-Hyun You is an associate project scientist in the Division of Nephrology-Hypertension,

Other DOM faculty coauthors are Sameh S. Ali, assistant professor of medicine in the Division of Geriatrics, and Robert K. Naviaux, MD, PhD, professor of medicine in the Division of Medical Genetics.

Citation for the study report:

Laura L. Dugan, Young-Hyun You, Sameh S. Ali, Maggie Diamond-Stanic, Satoshi Miyamoto, Anne-Emilie DeCleves, Aleksander Andreyev, Tammy Quach, San Ly, Grigory Shekhtman, William Nguyen, Andre Chepetan, Thuy P. Le, Lin Wang, Ming Xu, Kacie P. Paik, Agnes Fogo, Benoit Viollet, Anne Murphy, Frank Brosius, Robert K. Naviaux and Kumar Sharma. AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function. J Clin Invest. 2013;123(11):4888–4899. doi:10.1172/JCI66218.  |  Full text (UCSD only)

Related UC San Diego news stories:

Checkup Diabetes: the Latest Research and Treatments from UC San Diego

News Feature from the UC San Diego Health System Newsroom

Checkup Diabetes: the latest research and treatments at UC San Diego

by Scott LaFee

Diabetes is a monumental public health issue, not just because millions of Americans have been diagnosed with the metabolic disease, but also for the many more millions who either remain undiagnosed or have signs suggesting they will likely become diabetic. .. Read the full news feature from the UC San Diego Health System newsroom

Vitamin D Deficiency Linked to Type 1 Diabetes

 

A study led by researchers from the University of California, San Diego School of Medicine has found a correlation between vitamin D3 serum levels and subsequent incidence of Type 1 diabetes.  The six-year study of blood levels of nearly 2,000 individuals suggests a preventive role for vitamin D3 in this disease.  The research appears the December issue of Diabetologia, a publication of the European Association for the Study of Diabetes (EASD). … Read the full story from the UCSD Newsroom


Heather Hofflich, DOHeather Hofflich, DO, Health Sciences associate clinical professor in the Division of General Internal Medicine, is a coauthor of the report.

Citation for the report: Gorham ED, Garland CF, Burgi AA, Mohr SB, Zeng K, Hofflich H, Kim JJ, Ricordi C. Lower prediagnostic serum 25-hydroxyvitamin D concentration is associated with higher risk of insulin-requiring diabetes: a nested case–control study. Diabetologia 2012; 55:3224–3227. DOI: 10.1007/s00125-012-2709-8. Epub 2012 Sep 7. PMID:22955995.

$5.9 Million Grant to UC San Diego for Paradigm-Shifting Diabetes Research

Kumar Sharma, MD, FAHA, professor of medicine at the University of California, San Diego School of Medicine and director of the Center for Renal Translational Medicine, has received a $5.9 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health, to study kidney complications related to type 1 and type 2 diabetes…. Read the full story from the UCSD Newsroom


Kumar Sharma, MD, FAHADr. Sharma’s project, “Novel Paradigms in Diabetic Complications,” is a five-year Type 1 Diabetes Targeted Research Award.

Read the project abstract

Other Department of Medicine investigators in the project: