Four Common Antipsychotic Drugs Found to Lack Safety and Effectiveness in Older Adults

In older adults, antipsychotic drugs are commonly prescribed off-label for a number of disorders outside of their Food and Drug Administration (FDA)-approved indications – schizophrenia and bipolar disorder. The largest number of antipsychotic prescriptions in older adults is for behavioral disturbances associated with dementia, some of which carry FDA warnings on prescription information for these drugs.

In a new study – led by researchers at the University of California, San Diego School of Medicine, Stanford University and the University of Iowa, and funded by the National Institute of Mental Health – four of the antipsychotics most commonly prescribed off label for use in patients over 40 were found to lack both safety and effectiveness. … Read the full story from the UCSD Newsroom

Department of Medicine endocrinology and metabolism researchers Robert R. Henry, MD, and Sunder Mudaliar, MD, are coinvestigators in the study of the antipsychotic drugs.Dr. Robert R. Henry

Robert R. Henry, MD, is professor of medicine in the Division of Endocrinology & Metabolism at UC San Diego. At the Veterans Affairs San Diego Healthcare System (VASDHS), he is Chief of the Section of Endocrinology, Metabolism & Diabetes and Director of the Center for Metabolic Research.

Sunder Mudaliar, MD, is health sciences clinical professor in the Division of Endocrinology & Metabolism at UCSD. He is extensively involved in medical teaching and clinical care at the VASDHS. As an investigator in the Center for Metabolic Research, he performs clinical research focused on the prevention and treatment of diabetes.

More information:

Citation for the study report: Jin H, Shih PB,Golshan S, Mudaliar S, Henry R, Glorioso DK, Arndt S, Kraemer HC, Jeste DV. Comparison of Longer-Term Safety and Effectiveness of 4 Atypical Antipsychotics in Patients Over Age 40: A Trial Using Equipoise-Stratified Randomization. E-pub ahead of print, November 27, 2012, The Journal of Clinical Psychiatry.

Missing Molecule Raises Diabetes Risk in Humans

Researchers at the University of California, San Diego School of Medicine and Rady Children’s Hospital-San Diego say an evolutionary gene mutation that occurred in humans millions of years ago and our subsequent inability to produce a specific kind of sialic acid molecule appears to make people more vulnerable to developing type 2 diabetes, especially if they’re overweight. … Read the full story from the UCSD Newsroom

The authors of the study report include Ajit Varki, M.D. (pictured), Distinguished Professor of Medicine and Cellular & Molecular Medicine and co-director of both the Glycobiology Research and Training Center and the UC San Diego/Salk Center for Academic Research and Training in Anthropogeny (CARTA).   Read the published article (full text).

Endocrinology Researchers Uncover New Hope for Treating Type 2 Diabetes

Dr. Jerrold OlefskyDr. Jerrold M. Olefsky and colleagues have reported a discovery that suggests a new way to treat obesity-related insulin resistance and Type 2 diabetes.

In a laboratory study, they found that insulin resistance could be reversed by lowering the amount of adipose tissue macrophages (ATMs) in tissue.

ATMs normally help fight infection, but in obesity they accumulate in fat tissue and can become triggers for inflammation. The inflammation is a factor in the development of insulin resistance and Type 2 diabetes.

Jerrold M. Olefsky, M.D., is Distinguished Professor of Medicine in the Division of Endocrinology and Metabolism and Associate Dean for Scientific Affairs. Co-leader of the study is Jaap Neels, Ph.D., a former UCSD colleague.

Read the full story
from UC San Diego
Health Sciences Communications

Their Division of Endocrinology and Metabolism coauthors are researchers David Patsouris, Ph.D., Ping-Ping Li, and Divya Thapar.

The report is published in the October 8 issue of the journal Cell Metabolism. The full citation:

Patsouris D, Li PP, Thapar D, Chapman J, Olefsky JM, Neels JG. Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab 2008 Oct;8(4):301-309. Read the article abstract

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Dr. Joachim Ix and Coworkers Find Link Between Liver Protein and Type 2 Diabetes

A research team led by Dr. Joachim H. Ix has found that individuals who have higher levels of a particular liver protein are at a greater risk for developing Type 2 diabetes.

Dr. Joachim H. Ix, M.D., M.A.S., is Assistant Professor of Medicine in the Division of Nephrology.

The study, which included investigators from UC San Francisco and other U.S. Centers, is published in the Journal of the American Medical Association.The findings may lead to new methods for predicting who will develop Type 2 diabetes and treating the disease.

Read the full story from UC San Diego Health Sciences Communications

Ix JH, Wassel CL, Kanaya AM, Vittinghoff E, Johnson KC, Koster A, Cauley JA, Harris TB, Cummings SR, Shlipak MG for the Health ABC Study: Fetuin-A and Incident Diabetes Mellitus in Older Persons. JAMA 2008;300(2):182-188.
Read the report in JAMA

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 Read the San Diego Union-Tribune coverage